Evidence map›Paper›PMID 34880610›Full record

ArticleInternational journal of nanomedicine2021

Multiplexed Molecular Imaging Strategy Integrated with RNA Sequencing in the Assessment of the Therapeutic Effect of Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoporosis.

Cheng-Hsiu Lu, Yi-An Chen, Chien-Chih Ke, Sain-Jhih Chiu, Fong-Shya Jeng, Chao-Cheng Chen, Ya-Ju Hsieh, Bang-Hung Yang, Chi-Wei Chang, Feng-Sheng Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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  8. Extracellular derivatives for bone metabolism.Journal of advanced research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Cheng-Hsiu LuIndustrial Ph.D. Program of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0001-8428-1417
Yi-An ChenDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0002-8002-6256
Chien-Chih KeDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-9360-5476
Sain-Jhih ChiuMolecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei, Taiwan.
Fong-Shya JengMolecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei, Taiwan.
Chao-Cheng ChenDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ya-Ju HsiehDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0003-2082-9345
Bang-Hung YangDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chi-Wei ChangPET Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0003-4596-4682
Feng-Sheng WangCore Facility for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Ren-Shyan LiuIndustrial Ph.D. Program of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWElectronics Testing Center · TWKaohsiung Medical University · TWChang Gung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOsteoporosis is a result of an imbalance in bone remodeling. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been considered as a potentially promising treatment for osteoporosis. However, the therapeutic effect, genetic alterations, and in vivo behavior of exogenous EVs for osteoporosis in mice models remain poorly understood.

methodsA multiplexed molecular imaging strategy was constructed by micro-positron emission tomography (µPET)/computed tomography (CT), µCT, and optical imaging modality which reflected the osteoblastic activity, microstructure, and in vivo behavior of EVs, respectively. RNA sequencing was used to analyze the cargo of EVs, and the bone tissues of ovariectomized (OVX) mice post EV treatment.

resultsThe result of [

conclusionThe therapeutic effect of exogenous WJ-MSC-EVs in the treatment of osteoporosis was successfully assessed by a multiplexed molecular imaging strategy. The RNA sequencing demonstrated the possible molecular targets in the regulation of bone remodeling. The results highlight the novelty of diagnostic and therapeutic strategies of EV-based treatment for osteoporosis.

Indexed as

Extracellular VesiclesMesenchymal Stem CellsMicroRNAsOsteoporosisWharton JellyAnimalsMiceMolecular ImagingPhosphatidylinositol 3-KinasesSequence Analysis, RNAMicroRNAsMIRN29 microRNA, mousePhosphatidylinositol 3-Kinases[18F]NaFextracellular vesiclesosteoporosisRNA sequencingWharton’s jelly mesenchymal stem cells

Identifiers

PMID34880610
PMCPMC8646890
OpenAlexW3217310214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.