Evidence map›Paper›PMID 34880498›Full record

ArticleNature2021

Exercise plasma boosts memory and dampens brain inflammation via clusterin.

Zurine De Miguel, Nathalie Khoury, Michael J Betley, Benoit Lehallier, Drew Willoughby, Niclas Olsson, Andrew C Yang, Oliver Hahn, Nannan Lu, Ryan T Vest and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 4 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 4 syntheses or guidelines pooled it, 402 citations in OpenAlex.

  1. Pooled it
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  9. Lipid metabolism in moyamoya disease: Emerging evidence, vascular remodeling, and therapeutic implications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  14. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
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214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 1 country.

Zurine De MiguelDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nathalie Khoury *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Michael J Betley *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Benoit LehallierDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7452-3785
Drew WilloughbyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Niclas OlssonDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9746-0542
Andrew C YangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6756-4746
Oliver HahnDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Ryan T VestDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Liana N BonannoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Lakshmi YerraThe Veterans Affairs Palo Alto HealthCare System, Palo Alto, CA, USA.
Lichao ZhangChan Zuckerberg Biohub, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1811-7568
Nay Lui SawBehavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
J Kaci FairchildThe Veterans Affairs Palo Alto HealthCare System, Palo Alto, CA, USA.
Davis LeeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Hui ZhangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6787-7403
Patrick L McAlpineOtolaryngology Head and Neck Surgery Research Division, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9950-7156
Kévin ContrepoisDepartment of Genetics, Stanford University, Stanford, CA, USA.
Mehrdad ShamlooBehavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
Joshua E EliasDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Thomas A RandoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5843-8564
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Neurosciences Institute · USStanford University · USVA Palo Alto Health Care System · USChan Zuckerberg Initiative (United States) · USCalifornia State University, Monterey Bay · USEnzo Life Sciences (United States) · US

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS A. RANDO · 2011 to 2026
$29.3M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical ActivityR01AG047820 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A., WYSS-CORAY, TONY · 2013 to 2017
$3.5M
Aging and Stem Cell ResilienceR01AG068667 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2021 to 2025
$2.8M
Molecular Regulation of Stem Cell QuiescenceR01AR073248 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2018 to 2022
$2.6M
Epigenetic Reprogramming of Cellular AgeR01AG071783 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2021 to 2025
$2.2M
VCAM1 in brain endothelial cell activation in aging and Alzheimer's diseaseF32AG067652 · NIA · STANFORD UNIVERSITY · PI KHOURY, NATHALIE · 2020 to 2021
$84k
BLRD VA I01 BX001319NIA NIH HHS F32 AG067652NIA NIH HHS P01 AG036695NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG047820NIA NIH HHS R01 AG071783
6 · The paper itself

Abstract

Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration

Indexed as

Alzheimer DiseaseEncephalitisAnimalsClusterinEndothelial CellsHumansMiceProteomicsClusterin

Identifiers

PMID34880498
PMCPMC9721468
OpenAlexW4200434404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.