Evidence map›Paper›PMID 34880448›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2022

Lymphocyte-activation gene 3 in non-small-cell lung carcinomas: correlations with clinicopathologic features and prognostic significance.

Daniel J Shepherd, Elisabeth S Tabb, Keiko Kunitoki, M Lisa Zhang, Marina Kem, Jaimie Barth, David A Qualls, Meghan J Mooradian, Justin F Gainor, Mari Mino-Kenudson and 1 more

Open access · greenAbstract read
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Single-cell analysis reveals potential therapeutic markers of peripheral blood mononuclear cells from bladder cancer patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  4. Article
  5. Review
  6. LAG3 in gastric cancer: it's complicated.Journal of cancer research and clinical oncology · 2023
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Daniel J ShepherdDepartment of Pathology, Massachusetts General Hospital, Boston, USA.
Elisabeth S TabbDepartment of Pathology, Massachusetts General Hospital, Boston, USA.
Keiko KunitokiHarvard T.H. Chan School of Public Health, Boston, MA, USA.
M Lisa ZhangDepartment of Pathology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-8029-4787
Marina KemDepartment of Pathology, Massachusetts General Hospital, Boston, USA.
Jaimie BarthDepartment of Pathology, Massachusetts General Hospital, Boston, USA.
David A QuallsDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Meghan J MooradianDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Justin F GainorDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8697-4081
Mari Mino-Kenudson *Department of Pathology, Massachusetts General Hospital, Boston, USA. mminokenudson@partners.org.ORCID 0000-0002-9092-2265
Yin P Hung *Department of Pathology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-8568-1591
Harvard University · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · US

Funding

Patho-Genetic Analysis of Invasive Mucinous Adenocarcinoma of the LungR01CA240317 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI MAEDA, YUTAKA, SNYDER, ERIC LEE · 2020 to 2024
$3.1M
NCI NIH HHS R01 CA240317
6 · The paper itself

Abstract

Lymphocyte-activation gene 3 (LAG-3) modulates the tumor microenvironment through immunosuppressive effects. Its associations with clinicopathologic parameters and prognostic significance in non-small-cell lung carcinomas remain unclear. We examined LAG-3 expression in 368 resected non-small-cell lung carcinomas (including 218 adenocarcinomas and 150 squamous-cell carcinomas) using tissue microarrays, with normalization to CD8

Indexed as

AdenocarcinomaAntigens, CDCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellLung NeoplasmsB7-H1 AntigenCD8-Positive T-LymphocytesHumansLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingPrognosisTumor MicroenvironmentAntigens, CDB7-H1 AntigenLag3 protein, humanLymphocyte Activation Gene 3 Protein

Identifiers

PMID34880448
PMCPMC9050756
OpenAlexW4200349683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.