Evidence map›Paper›PMID 34880444›Full record

ReviewPediatric research2022

Invasive fungal infections in neonates: a review.

Kristin E D Weimer, P Brian Smith, Mihai Puia-Dumitrescu, Samia Aleem

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Voriconazole and Dexamethasone Drug Interaction in a Premature Neonate.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  6. An invasiveMedical mycology case reports · 2026
    Article
  7. Bacterial and fungal infections in infants born before 24 weeks' gestation: a review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Article
  17. Review
  18. Article
  19. Cranial ultrasound in neonatal brain infections.Developmental medicine and child neurology · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Kristin E D WeimerDivision of Neonatology, Department of Pediatrics, Duke University, Durham, NC, UK.
P Brian SmithDivision of Neonatology, Department of Pediatrics, Duke University, Durham, NC, UK.
Mihai Puia-DumitrescuDivision of Neonatology, Department of Pediatrics, University of Washington | Seattle Children's Hospital, Seattle, WA, USA. mihaipd@uw.edu.
Samia AleemDivision of Neonatology, Department of Pediatrics, Duke University, Durham, NC, UK.
Duke University · USDurham University · GBSeattle Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive fungal infections remain the leading causes of morbidity and mortality in neonates, especially preterm and very low birth weight infants. Most invasive fungal infections are due to Candida or Aspergillus species, and other fungi are increasingly reported and described. Appropriate identification and treatment are required to augment activity and reduce the toxicity of antifungal drugs. Successful use of antifungals in the vulnerable neonatal population is important for both prevention and treatment of infection. Strategies for prevention, including prophylactic antifungal therapy as well as reducing exposure to modifiable risk factors, like limiting antibiotic exposure, discontinuation of central catheters, and hand hygiene are key techniques to prevent and decrease rates of invasive fungal infections. In conclusion, this is a review of the most common causes, prevention strategies, prophylaxis, and treatment of invasive fungal infections in neonates.

Indexed as

Antifungal AgentsHumansImmunocompromised HostInfant, NewbornInfant, Newborn, DiseasesInvasive Fungal InfectionsRisk FactorsAntifungal Agents

Identifiers

PMID34880444
OpenAlexW4200005696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.