Yeppoonic acids A - D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp.

Heather Lacey, Rachel Chen, Daniel Vuong, Michael S Cowled, Ernest Lacey, Peter J Rutledge, Andrew M Piggott

Abstract read

In one paragraph

Article in The Journal of antibiotics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Heather LaceySchool of Chemistry, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia. hlac5959@uni.sydney.edu.au.ORCID 0000-0001-5332-8470

Rachel ChenMicrobial Screening Technologies, Smithfield, Sydney, NSW, 2164, Australia.

Daniel VuongMicrobial Screening Technologies, Smithfield, Sydney, NSW, 2164, Australia.

Michael S CowledDepartment of Molecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia.

Ernest LaceyMicrobial Screening Technologies, Smithfield, Sydney, NSW, 2164, Australia.

Peter J RutledgeSchool of Chemistry, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.ORCID 0000-0002-0767-5196

Andrew M PiggottDepartment of Molecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia.

Macquarie University · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptomyces sp. MST-91080 was isolated from a soil sample collected in Queensland, Australia. From this strain, yeppoonic acids A - D were purified and spectroscopically characterised. The yeppoonic acids are a family of diene enecarboxylic acids on a 1,2,4-trisubstituted benzene scaffold, structurally related to other Streptomyces secondary metabolites MF-EA-705α/β, NFAT-133 and the lorneic acids. Yeppoonic acids B and C show strong cytotoxicity against the NS-1 mouse myeloma cell line (IC

Indexed as

AnimalsAnti-Bacterial AgentsAntibiotics, AntineoplasticAustraliaCarboxylic AcidsCell Line, TumorHumansMaleMiceMultiple MyelomaOxazolesProstatic NeoplasmsQueenslandSoil MicrobiologyStreptomycesAnti-Bacterial AgentsAntibiotics, AntineoplasticCarboxylic AcidsconglobatinOxazoles

Identifiers

PMID34880415

DOI10.1038/s41429-021-00493-4

OpenAlexW4200246074

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.