Evidence map›Paper›PMID 34880410›Full record

ArticleNPJ digital medicine2021

Forecasting adverse surgical events using self-supervised transfer learning for physiological signals.

Hugh Chen, Scott M Lundberg, Gabriel Erion, Jerry H Kim, Su-In Lee

Abstract read
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. [Research progress on electronic health records multimodal data fusion based on deep learning].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
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  15. COVID-19 detection based on self-supervised transfer learning using chest X-ray images.International journal of computer assisted radiology and surgery · 2023
    Article
  16. Article
  17. Article
  18. Artificial intelligence and anesthesia: a narrative review.Annals of translational medicine · 2022
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hugh ChenPaul G. Allen School of Computer Science and Engineering, University of Washington, 185 E Stevens Way NE, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0003-0549-4524
Scott M LundbergMicrosoft Research, 14820 NE 36th St, Redmond, WA, 98052, USA.
Gabriel ErionPaul G. Allen School of Computer Science and Engineering, University of Washington, 185 E Stevens Way NE, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0001-8741-131X
Jerry H KimGlobal Innovation Exchange, University of Washington, 12280 NE District Wy, Bellevue, WA, 98005, USA.
Su-In LeePaul G. Allen School of Computer Science and Engineering, University of Washington, 185 E Stevens Way NE, Seattle, WA, 98195, USA. suinlee@cs.washington.edu.ORCID http://orcid.org/0000-0001-5833-5215

Funding

Interpretable Machine Learning to Identify Alzheimer's Disease Therapeutic TargetsR01AG061132 · NIA · UNIVERSITY OF WASHINGTON · PI LEE, SU-IN · 2019 to 2023
$2.9M
Opening the Black Box of Machine Learning ModelsR35GM128638 · NIGMS · UNIVERSITY OF WASHINGTON · PI LEE, SU-IN · 2018 to 2022
$1.9M
NIA NIH HHS R01 AG061132NIGMS NIH HHS R35 GM128638
6 · The paper itself

Abstract

Hundreds of millions of surgical procedures take place annually across the world, which generate a prevalent type of electronic health record (EHR) data comprising time series physiological signals. Here, we present a transferable embedding method (i.e., a method to transform time series signals into input features for predictive machine learning models) named PHASE (PHysiologicAl Signal Embeddings) that enables us to more accurately forecast adverse surgical outcomes based on physiological signals. We evaluate PHASE on minute-by-minute EHR data of more than 50,000 surgeries from two operating room (OR) datasets and patient stays in an intensive care unit (ICU) dataset. PHASE outperforms other state-of-the-art approaches, such as long-short term memory networks trained on raw data and gradient boosted trees trained on handcrafted features, in predicting six distinct outcomes: hypoxemia, hypocapnia, hypotension, hypertension, phenylephrine, and epinephrine. In a transfer learning setting where we train embedding models in one dataset then embed signals and predict adverse events in unseen data, PHASE achieves significantly higher prediction accuracy at lower computational cost compared to conventional approaches. Finally, given the importance of understanding models in clinical applications we demonstrate that PHASE is explainable and validate our predictive models using local feature attribution methods.

Identifiers

PMID34880410
PMCPMC8654960

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.