Evidence map›Paper›PMID 34880366›Full record

ArticleNPJ digital medicine2021

Passive detection of COVID-19 with wearable sensors and explainable machine learning algorithms.

Matteo Gadaleta, Jennifer M Radin, Katie Baca-Motes, Edward Ramos, Vik Kheterpal, Eric J Topol, Steven R Steinhubl, Giorgio Quer

Abstract read
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. MS Pattern Explorer: interactive visual exploration of temporal activity patterns for multiple sclerosis.Journal of the American Medical Informatics Association : JAMIA · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matteo GadaletaScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0001-6470-6537
Jennifer M RadinScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0003-3843-0842
Katie Baca-MotesScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA.
Edward RamosScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA.
Vik KheterpalCareEvolution, 625N Main Street, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0002-4752-4229
Eric J TopolScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA.
Steven R SteinhublScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-9256-7914
Giorgio QuerScripps Research Translational Institute, 3344N Torrey Pines Ct Plaza Level, La Jolla, CA, 92037, USA. gquer@scripps.edu.ORCID http://orcid.org/0000-0003-2208-7912

Funding

Scripps Translational Science InstituteUL1TR002550 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2018 to 2022
$28.9M
National Science Foundation (NSF) OIA-2040727NCATS NIH HHS UL1 TR002550U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002550
6 · The paper itself

Abstract

Individual smartwatch or fitness band sensor data in the setting of COVID-19 has shown promise to identify symptomatic and pre-symptomatic infection or the need for hospitalization, correlations between peripheral temperature and self-reported fever, and an association between changes in heart-rate-variability and infection. In our study, a total of 38,911 individuals (61% female, 15% over 65) have been enrolled between March 25, 2020 and April 3, 2021, with 1118 reported testing positive and 7032 negative for COVID-19 by nasopharyngeal PCR swab test. We propose an explainable gradient boosting prediction model based on decision trees for the detection of COVID-19 infection that can adapt to the absence of self-reported symptoms and to the available sensor data, and that can explain the importance of each feature and the post-test-behavior for the individuals. We tested it in a cohort of symptomatic individuals who exhibited an AUC of 0.83 [0.81-0.85], or AUC = 0.78 [0.75-0.80] when considering only data before the test date, outperforming state-of-the-art algorithm in these conditions. The analysis of all individuals (including asymptomatic and pre-symptomatic) when self-reported symptoms were excluded provided an AUC of 0.78 [0.76-0.79], or AUC of 0.70 [0.69-0.72] when considering only data before the test date. Extending the use of predictive algorithms for detection of COVID-19 infection based only on passively monitored data from any device, we showed that it is possible to scale up this platform and apply the algorithm in other settings where self-reported symptoms can not be collected.

Identifiers

PMID34880366
PMCPMC8655005

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.