Evidence map›Paper›PMID 34880341›Full record

ArticleScientific reports2021

Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion.

Antonio Letrán, Ignacio García, Marisa Espinazo-Romeu, Carmen Moreno-Aguilar, Francisco Moreno

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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  4. Focused allergic rhinitis practice parameter for Canada.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
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  6. [Characteristics of allergen component in dust mite-induced allergic rhinitis patients].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
  7. Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Antonio Letrán *Servicio de Alergología e Inmunología, CM ASISA Lobatón, Cádiz, Spain.
Ignacio García *University of Cordoba, Cordoba, Spain.
Marisa Espinazo-RomeuGC01 Laboratorio de Inmunología y Alergia, Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Avenida Menéndez Pidal, S/N, 14004, Córdoba, Spain. marialuisa.espinazo@imibic.org.
Carmen Moreno-AguilarGC01 Laboratorio de Inmunología y Alergia, Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Avenida Menéndez Pidal, S/N, 14004, Córdoba, Spain.
Francisco MorenoServicio de Alergología e Inmunología, CM ASISA Lobatón, Cádiz, Spain.
University of Córdoba · ESHospital Universitario Reina Sofía · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accessibility to more precise diagnostic techniques such as component resolved diagnostics (CRD), provides us with an important advance in diagnostic aspects as well as treatment. The subject of this study aims to better understand the profiles of sensitization to Der p 1, Der p 2 and Der p 23 and to know to what extent their use could help us in optimizing the decision-making for their treatment with Specific Immunotherapy. Cross-sectional study of subjects older than 5 years, diagnosed with allergy to HDM using skin prick test and sIgE, with symptoms of rhinitis and/or asthma. Total and specific IgE was determined to D. pteronyssinus, nDer p 1, rDer p 2 and rDer p 23 using ImmunoCAP. 240 patients were recruited (97.1% rhinitis and 46.25% rhinitis and asthma). Four different phenotypes were observed: positive or negative for sIgE nDer p 1 and/or IgE rDer p 2. 17% of these patients sIgE were double negative for Der p 1 and Der p 2 (increasing with age and with significantly lower sIgE levels than the rest of the groups). Using ROC curves, value less than 2.18 KU

Indexed as

AdultAllergensAnimalsAntigens, DermatophagoidesArthropod ProteinsAsthmaCross-Sectional StudiesCysteine EndopeptidasesDermatophagoides pteronyssinusFemaleHumansImmunoglobulin EMaleRhinitisRhinitis, AllergicSkin TestsAllergensAntigens, DermatophagoidesArthropod ProteinsCysteine EndopeptidasesDermatophagoides pteronyssinus antigen p 1Dermatophagoides pteronyssinus antigen p 2Immunoglobulin E

Identifiers

PMID34880341
PMCPMC8655041
OpenAlexW4200407946

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.