Evidence map›Paper›PMID 34880299›Full record

ArticleScientific reports2021

Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells.

Xuyen T Dinh, Dragana Stanley, Letitia D Smith, Morgane Moreau, Stuart P Berzins, Adrian Gemiarto, Alan G Baxter, Margaret A Jordan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Protective effects ofFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xuyen T DinhMolecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, The Science Place, Building 142, James Cook University, Townsville, QLD, 4811, Australia.
Dragana StanleySchool of Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD, 4702, Australia.
Letitia D SmithMolecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, The Science Place, Building 142, James Cook University, Townsville, QLD, 4811, Australia.
Morgane MoreauMolecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, The Science Place, Building 142, James Cook University, Townsville, QLD, 4811, Australia.
Stuart P BerzinsSchool of Science, Psychology and Sport, Federation University Australia, Ballarat, VIC, 3350, Australia.
Adrian GemiartoMolecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, The Science Place, Building 142, James Cook University, Townsville, QLD, 4811, Australia.
Alan G Baxter *Molecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, The Science Place, Building 142, James Cook University, Townsville, QLD, 4811, Australia.
Margaret A Jordan *Molecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, The Science Place, Building 142, James Cook University, Townsville, QLD, 4811, Australia. Margaret.Jordan@jcu.edu.au.
James Cook University · AUCentral Queensland University · AUFederation University · AUUniversity of Hai Duong · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed by CD4

Indexed as

Cell LineageSignal TransductionAnimalsAntigens, CD1dMiceMice, Inbred NODMice, TransgenicNatural Killer T-CellsReceptors, Antigen, T-CellAntigens, CD1dCD1D protein, humanReceptors, Antigen, T-Cell

Identifiers

PMID34880299
PMCPMC8655039
OpenAlexW4200194001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.