Evidence map›Paper›PMID 34880279›Full record

ArticleScientific reports2021

Hotspots for mutations in the SARS-CoV-2 spike glycoprotein: a correspondence analysis.

Mohammad Reza Rahbar, Abolfazl Jahangiri, Saeed Khalili, Mahboubeh Zarei, Kamran Mehrabani-Zeinabad, Bahman Khalesi, Navid Pourzardosht, Anahita Hessami, Navid Nezafat, Saman Sadraei and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Mohammad Reza RahbarPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abolfazl JahangiriApplied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Saeed KhaliliDepartment of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.
Mahboubeh ZareiPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Kamran Mehrabani-ZeinabadDepartment of Biostatistics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Bahman KhalesiDepartment of Research and Production of Poultry Viral Vaccine, Razi Vaccine, and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran.
Navid PourzardoshtCellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Anahita HessamiSchool of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Navid NezafatPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Saman SadraeiPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Manica NegahdaripourPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. monica.negahdaripour@yahoo.com.
Shiraz University of Medical Sciences · IRAgricultural Research & Education Organization · IRBaqiyatallah University of Medical Sciences · IRGuilan University of Medical Sciences · IRShahid Rajaee Teacher Training University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spike glycoprotein (Sgp) is liable for binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the host receptors. Since Sgp is the main target for vaccine and drug designing, elucidating its mutation pattern could help in this regard. This study is aimed at investigating the correspondence of specific residues to the Sgp

Indexed as

Amino Acid SequenceAngiotensin-Converting Enzyme 2Binding SitesCluster AnalysisCOVID-19HumansMarkov ChainsMutationProtein BindingProtein DomainsSARS-CoV-2Sequence AlignmentSpike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID34880279
PMCPMC8654821
OpenAlexW4200422556

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.