Evidence map›Paper›PMID 34880260›Full record

ArticleNature communications2021

Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia.

Jit Chatterjee, Shilpa Sanapala, Olivia Cobb, Alice Bewley, Andrea K Goldstein, Elizabeth Cordell, Xia Ge, Joel R Garbow, Michael J Holtzman, David H Gutmann

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Decorin: matrix-based pan-cancer tumor suppressor.Molecular and cellular biochemistry · 2025
    Review
  12. Article
  13. Precision preclinical modeling to advance cancer treatment.Journal of the National Cancer Institute · 2025
    Review
  14. Association of immunoglobulin E levels with glioma risk and survival.Journal of the National Cancer Institute · 2025
    Article
  15. Article
  16. Low-grade glioma in children with neurofibromatosis type 1: surveillance, treatment indications, management, and future directions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  17. Association of immunoglobulin E levels with glioma risk and survival.medRxiv : the preprint server for health sciences · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jit ChatterjeeDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Shilpa SanapalaDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Olivia CobbDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Alice BewleyDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Andrea K GoldsteinDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Elizabeth CordellDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Xia GeMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Joel R GarbowMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Michael J HoltzmanDepartment of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8750-3716
David H GutmannDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. gutmannd@wustl.edu.ORCID http://orcid.org/0000-0002-3127-5045
Washington University in St. Louis · USMallinckrodt (United States) · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
Defining and Controlling Airway DiseaseR35HL145242 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2019 to 2025
$6.6M
SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHOT35HL007815 · NHLBI · WASHINGTON UNIVERSITY · PI CHUNG, KOONG-NAH · 1995 to 2020
$2.8M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NEI NIH HHS P30 EY002687NHLBI NIH HHS R35 HL145242NHLBI NIH HHS T35 HL007815
6 · The paper itself

Abstract

To elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic pathway glioma (Nf1

Indexed as

GliomaAnimalsAsthmaBrain NeoplasmsChemokine CCL4Chemokine CCL5DecorinDisease Models, AnimalMiceMice, Inbred C57BLMicrogliaMonitoring, ImmunologicNeurofibromatosis 1Neurofibromin 1Optic NerveOptic Nerve GliomaCcl4 protein, mouseCcl5 protein, mouseChemokine CCL4Chemokine CCL5DecorinNeurofibromin 1

Identifiers

PMID34880260
PMCPMC8654836
OpenAlexW4200550757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.