ArticleNature communications2021
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Article
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Extracellular matrix remodelling in neurological diseases.Nature reviews. Neurology · 2026Review
- The extracellular matrix as a dynamic regulator of brain function and plasticity.Neurobiology of disease · 2026Review
- Extracellular matrix proteolysis maintains synapse plasticity during brain development.Nature neuroscience · 2026Article
- Extracellular matrix and perineuronal nets in neural plasticity, memory, and epileptogenesis.Frontiers in molecular neuroscience · 2026Review
- Decellularized vascular matrix material-based TEVG coated with PRP for anti-degradation and anti-inflammation.International journal of surgery (London, England) · 2026Article
- The Neuronal Golgi Network and Its Acolytes.Sub-cellular biochemistry · 2026Review
- Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural plasticity.EMBO reports · 2026Article
- A Prognostic 9-Gene Signature Linked to Autophagy-Dependent Cell Death in Hepatocellular Carcinoma.Cancer informatics · 2026Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Carbon Nanotube Hydrogels Reveal Threshold-Dependent Regulation of Neuroblastoma Cell Growth and Maturation by Mechanical and Chemical Factors.Small science · 2025Article
- Membrane trafficking of synaptic adhesion molecules.The Journal of physiology · 2025Review
- Enhanced fear extinction through infralimbic perineuronal net digestion: The modulatory role of adolescent alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2025Article
- Perineuronal Nets: From Structure to Neurological Disorders.Current medicinal chemistry · 2025Review
- Mechanisms of assembly and remodelling of the extracellular matrix.Nature reviews. Molecular cell biology · 2024Review
- Acid-degradable lipid nanoparticles enhance the delivery of mRNA.Nature nanotechnology · 2024Article
- Enhanced Fear Extinction Through Infralimbic Perineuronal Net Digestion: The Modulatory Role of Adolescent Alcohol Exposure.bioRxiv : the preprint server for biology · 2024Article
- Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy-Lysosome Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.Cell reports · 2024Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain extracellular matrix (ECM) consists of extremely long-lived proteins that assemble around neurons and synapses, to stabilize them. The ECM is thought to change only rarely, in relation to neuronal plasticity, through ECM proteolysis and renewed protein synthesis. We report here an alternative ECM remodeling mechanism, based on the recycling of ECM molecules. Using multiple ECM labeling and imaging assays, from super-resolution optical imaging to nanoscale secondary ion mass spectrometry, both in culture and in brain slices, we find that a key ECM protein, Tenascin-R, is frequently endocytosed, and later resurfaces, preferentially near synapses. The TNR molecules complete this cycle within ~3 days, in an activity-dependent fashion. Interfering with the recycling process perturbs severely neuronal function, strongly reducing synaptic vesicle exo- and endocytosis. We conclude that the neuronal ECM can be remodeled frequently through mechanisms that involve endocytosis and recycling of ECM proteins.
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