ArticleNature communications2021
Ir-catalyzed enantioselective B-H alkenylation for asymmetric synthesis of chiral-at-cage o‑carboranes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Site-Selective B─H Activation via HAT Toward Xanthyl-closo-Carboranes as Bench-Stable Precursors of Organosulfur Boron Clusters.Angewandte Chemie (International ed. in English) · 2026Article
- Iridium(III)-catalyzed remote B(9)-H alkylation of o-carboranes with nitrile template.Nature communications · 2025Article
- Post-coordination of Ru(ii) controlled regioselective B(4)-H acylmethylation ofChemical science · 2025Article
- Site- and enantioselective B-H functionalization of carboranes.Nature communications · 2025Article
- Couple-close construction of non-classical boron cluster-phosphonium conjugates.Nature communications · 2024Article
- A Pd-catalyzed route to carborane-fused boron heterocycles.Chemical science · 2024Article
- Palladium-Catalyzed Regioselective B(3,5)-Dialkenylation and B(4)-Alkenylation ofThe Journal of organic chemistry · 2024Article
- Synthesis and Structural Characterization ofMolecules (Basel, Switzerland) · 2023Article
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5 authors.
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Abstract
The asymmetric synthesis of chiral-at-cage o-carboranes, whose chirality is associated with the substitution patterns on the polyhedron, is of great interest as the icosahedral carboranes have wide applications in medicinal and materials chemistry. Herein we report an intermolecular Ir-catalyzed enantioselective B-H alkenylation for efficient and facile synthesis of chiral-at-cage o-carboranes with new skeletons under mild reaction conditions. Generally very good to excellent yields with up to 99% ee can be achieved in this Ir-catalyzed B-H alkenylation. The enantiocontrol model is proposed based on Density Functional Theory calculations in which the use of chiral phosphoramidite ligand is essential for such asymmetric o-carborane B-H alkenylation.
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