Evidence map›Paper›PMID 34880135›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates.

Sabyasachi Das, Jonathan P Rast, Jianxu Li, Mitsutaka Kadota, John A Donald, Shigehiro Kuraku, Masayuki Hirano, Max D Cooper

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 35 citations in OpenAlex.

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  9. Adaptive immune receptor genotyping using theFrontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Sabyasachi DasDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; mdcoope@emory.edu sdas8@emory.edu.
Jonathan P RastDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322.
Jianxu LiDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322.
Mitsutaka KadotaLaboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research, 650-0047 Kobe, Japan.
John A DonaldSchool of Life and Environmental Sciences, Deakin University, Geelong, VIC 3220, Australia.
Shigehiro KurakuLaboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research, 650-0047 Kobe, Japan.
Masayuki HiranoDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322.
Max D CooperDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322; mdcoope@emory.edu sdas8@emory.edu.
Emory University · USDeakin University · AURIKEN Center for Biosystems Dynamics Research · JPThe Graduate University for Advanced Studies, SOKENDAI · JP

Funding

Characterization of the Lamprey Adaptive Immune SystemR01AI072435 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Max Dale Cooper · 2007 to 2026
$8.1M
T Cell Differentiation and Diversification in Jawless Vertebrates: Administrative Supplement for purchase of Laser Capture MicroscopeR35GM122591 · NIGMS · EMORY UNIVERSITY · PI Max Dale Cooper · 2017 to 2026
$4.7M
Characterization of an Alternative Adaptive Immune System in HagfishR01GM108838 · NIGMS · EMORY UNIVERSITY · PI COOPER, MAX DALE · 2014 to 2016
$889k
NIAID NIH HHS R01 AI072435NIGMS NIH HHS R01 GM108838NIGMS NIH HHS R35 GM122591
6 · The paper itself

Abstract

Three types of variable lymphocyte receptor (VLR) genes,

Indexed as

PhylogenyAnimalsAntibodiesGenetic VariationHagfishesLampreysLeucine-Rich Repeat ProteinsLymphocytesSpecies SpecificityAntibodiesLeucine-Rich Repeat Proteinsadaptive immunityimmune system evolutionjawless vertebratestransposable elementsvariable lymphocyte receptor

Identifiers

PMID34880135
PMCPMC8685922
OpenAlexW4200473315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.