ArticleProceedings of the National Academy of Sciences of the United States of America2021
The hippocampus as the switchboard between perception and memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Stereo-EEG mapping of visual working memory with task-related high-gamma modulations.Epilepsia · 2026Article
- Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease.CNS neuroscience & therapeutics · 2026Article
- Microstructural Integrity of Hippocampal-Posterior Cortical White Matter Is Associated With Phenomenological Properties of Trauma-Related Intrusive Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Respiration Shapes the Neural Dynamics of Successful Remembering in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway.Frontiers in aging neuroscience · 2026Article
- Concurrent selection of internal goals and external sensations during visual search.Science advances · 2025Article
- Episodic memory involves transient and sparse connectivity aligned to both internal and external events.PLoS biology · 2025Article
- Impaired neural activity and functional connectivity in the hippocampus of adolescents with non-suicidal self-injury addiction.BMC psychiatry · 2025Article
- The Effects of External Cue Overlap and Internal Goals on Selective Memory Retrieval as Revealed by Electroencephalographic (EEG) Neural Pattern Reinstatement.The European journal of neuroscience · 2025Article
- Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.Science advances · 2025Article
- Amplitude of Intracranial Induced Electric Fields Does Not Linearly Decrease with Age: A Computational Study of Anatomical Effects in Adults.Biosensors · 2025Article
- Reinstatement and transformation of memory traces for recognition.Science advances · 2025Article
- Shaping the Space: A Role for the Hippocampus in Mental Imagery Formation.Vision (Basel, Switzerland) · 2025Review
- Distributed and gradual microstructure changes are associated with the emergence of behavioural benefit from memory reactivation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Visual imagery of familiar people and places in category selective cortex.Neuroscience of consciousness · 2025Article
- Neural dynamics of shifting attention between perception and working-memory contents.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- [Analysis of nerve excitability in the dentate gyrus of the hippocampus in cerebral ischaemia-reperfusion mice].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia.eLife · 2024Article
- EEG Techniques with Brain Activity Localization, Specifically LORETA, and Its Applicability in Monitoring Schizophrenia.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Adaptive memory recall requires a rapid and flexible switch from external perceptual reminders to internal mnemonic representations. However, owing to the limited temporal or spatial resolution of brain imaging modalities used in isolation, the hippocampal-cortical dynamics supporting this process remain unknown. We thus employed an object-scene cued recall paradigm across two studies, including intracranial electroencephalography (iEEG) and high-density scalp EEG. First, a sustained increase in hippocampal high gamma power (55 to 110 Hz) emerged 500 ms after cue onset and distinguished successful vs. unsuccessful recall. This increase in gamma power for successful recall was followed by a decrease in hippocampal alpha power (8 to 12 Hz). Intriguingly, the hippocampal gamma power increase marked the moment at which extrahippocampal activation patterns shifted from perceptual cue toward mnemonic target representations. In parallel, source-localized EEG alpha power revealed that the recall signal progresses from hippocampus to posterior parietal cortex and then to medial prefrontal cortex. Together, these results identify the hippocampus as the switchboard between perception and memory and elucidate the ensuing hippocampal-cortical dynamics supporting the recall process.
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