Evidence map›Paper›PMID 34880111›Full record

ArticleeNeuro

Protein Profiling of RGS6, a Pleiotropic Gene Implicated in Numerous Neuropsychiatric Disorders, Reveals Multi-Isoformic Expression and a Novel Brain-Specific Isoform.

K E Ahlers-Dannen, J Yang, M M Spicer, B Maity, A Stewart, J G Koland, R A Fisher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

K E Ahlers-DannenDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
J YangDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
M M SpicerDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
B MaityDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
A StewartDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
J G KolandDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
R A FisherDepartment of Neuroscience and Pharmacology, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242 rory-fisher@uiowa.edu.
University of Iowa · US

Funding

RGS6 in mesolimbic circuits as a therapeutic target for alcohol use disordersR01AA025919 · NIAAA · UNIVERSITY OF IOWA · PI FISHER, RORY A. · 2018 to 2022
$2.8M
Molecular Analysis and Role of RGS6 as a Novel Growth SuppressorR01CA161882 · NCI · UNIVERSITY OF IOWA · PI FISHER, RORY A. · 2012 to 2016
$1.5M
NCI NIH HHS R01 CA161882NIAAA NIH HHS R01 AA025919
6 · The paper itself

Abstract

A metanalysis identified regulator of G-protein signaling 6 (

Indexed as

Genetic PleiotropyRGS ProteinsAnimalsBrainGTP-Binding ProteinsMiceProtein IsoformsGTP-Binding ProteinsProtein IsoformsRgs6 protein, mouseRGS ProteinsexpressionisoformsneuropsychiatricpleiotropicRGS6splicing

Identifiers

PMID34880111
PMCPMC8805202
OpenAlexW4200206480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.