Evidence map›Paper›PMID 34880089›Full record

ArticleNeurology2022

Association of Air Pollution and Physical Activity With Brain Volumes.

Melissa A Furlong, Gene E Alexander, Yann C Klimentidis, David A Raichlen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  5. PMScientific reports · 2025
    Article
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  8. Association of white matter hyperintensities with BMD, incident fractures, and falls in the UK Biobank cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Air Pollution-Related Neurotoxicity Across the Life Span.Annual review of pharmacology and toxicology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melissa A FurlongFrom the Department of Community, Environment, and Policy (M.A.F.), Mel and Enid Zuckerman College of Public Health, Departments of Psychology and Psychiatry (G.E.A.), Evelyn F. McKnight Brain Institute (G.E.A.), BIO5 Institute (G.E.A., Y.C.K.), Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs (G.E.A.), and Department of Epidemiology and Biostatistics (Y.C.K.), University of Arizona, Tucson; Arizona Alzheimer's Consortium (G.E.A.), Phoenix; and Human and Evolutionary Biology Section (D.A.R.), Department of Biological Sciences, University of Southern California, Los Angeles. mfurlong@email.arizona.edu.
Gene E AlexanderFrom the Department of Community, Environment, and Policy (M.A.F.), Mel and Enid Zuckerman College of Public Health, Departments of Psychology and Psychiatry (G.E.A.), Evelyn F. McKnight Brain Institute (G.E.A.), BIO5 Institute (G.E.A., Y.C.K.), Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs (G.E.A.), and Department of Epidemiology and Biostatistics (Y.C.K.), University of Arizona, Tucson; Arizona Alzheimer's Consortium (G.E.A.), Phoenix; and Human and Evolutionary Biology Section (D.A.R.), Department of Biological Sciences, University of Southern California, Los Angeles.
Yann C KlimentidisFrom the Department of Community, Environment, and Policy (M.A.F.), Mel and Enid Zuckerman College of Public Health, Departments of Psychology and Psychiatry (G.E.A.), Evelyn F. McKnight Brain Institute (G.E.A.), BIO5 Institute (G.E.A., Y.C.K.), Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs (G.E.A.), and Department of Epidemiology and Biostatistics (Y.C.K.), University of Arizona, Tucson; Arizona Alzheimer's Consortium (G.E.A.), Phoenix; and Human and Evolutionary Biology Section (D.A.R.), Department of Biological Sciences, University of Southern California, Los Angeles.ORCID http://orcid.org/0000-0002-6065-4044
David A RaichlenFrom the Department of Community, Environment, and Policy (M.A.F.), Mel and Enid Zuckerman College of Public Health, Departments of Psychology and Psychiatry (G.E.A.), Evelyn F. McKnight Brain Institute (G.E.A.), BIO5 Institute (G.E.A., Y.C.K.), Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs (G.E.A.), and Department of Epidemiology and Biostatistics (Y.C.K.), University of Arizona, Tucson; Arizona Alzheimer's Consortium (G.E.A.), Phoenix; and Human and Evolutionary Biology Section (D.A.R.), Department of Biological Sciences, University of Southern California, Los Angeles.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Epigenetic, Neuroimaging & Behavioral Effects of Hypertension in the Aging BrainR01AG049464 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, BARNES, CAROL A. · 2014 to 2018
$2.4M
Physical activity predictors of cognitive and brain health in the risk for Alzheimer's diseaseR56AG067200 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, RAICHLEN, DAVID · 2020 to 2020
$767k
Prenatal Exposure to Pesticide Mixtures and Childhood ADHDR00ES028743 · NIEHS · UNIVERSITY OF ARIZONA · PI FURLONG, MELISSA · 2020 to 2022
$747k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG049464NIA NIH HHS R56 AG067200NIEHS NIH HHS R00 ES028743
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn high-pollution areas, physical activity may have a paradoxical effect on brain health by increasing particulate deposition in the lungs. We examined whether physical activity modifies associations of air pollution (AP) with brain volumes in an epidemiologic framework.

methodsThe UK Biobank enrolled >500,000 adult participants from 2006 to 2010. Wrist accelerometers, multimodal MRI with T1 images and T2 fluid-attenuated inversion recovery data, and land use regression were used to estimate vigorous physical activity (VigPA), structural brain volumes, and AP, respectively, in subsets of the full sample. We evaluated associations among AP interquartile ranges, VigPA, and brain structure volumes and assessed interactions between AP and VigPA.

resultsEight thousand six hundred participants were included, with an average age of 55.55 (SD 7.46) years. After correction for multiple testing, in overall models, VigPA was positively associated with gray matter volume (GMV) and negatively associated with white matter hyperintensity volume (WMHV), while NO

Identifiers

PMID34880089
PMCPMC8793107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.