Observational studyBMJ open diabetes research & care2021
Clinical and biochemical profile of 786 sequential episodes of diabetic ketoacidosis in adults with type 1 and type 2 diabetes mellitus.
Observational study in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic literature review on the burden of diabetic ketoacidosis in type 2 diabetes mellitus.Diabetes, obesity & metabolism · 2025Pooled it
- Biochemical profiles and precipitating factors of diabetic ketoacidosis among type 1 and type 2 diabetes patients: a retrospective analysis from Syria.BMC endocrine disorders · 2026Article
- Clinically significant hypoglycaemia in hospitalised adults: A multicentre study of 1205 episodes in the United Kingdom.Diabetic medicine : a journal of the British Diabetic Association · 2026Observational
- Time to Resolution of Diabetic Ketoacidosis and Its Predictors among Adult Diabetic Patients in Public Hospitals of Northeast, Ethiopia.Scientific reports · 2026Article
- Age and sex differences in diabetic ketoacidosis outcomes in type 1 diabetes: a national cohort study.BMJ open diabetes research & care · 2026Article
- Implementing a multi-centre hypoglycaemia management surveillance model through a co-designed approach to develop actionable insights in the UK.Frontiers in health services · 2026Article
- Sex Differences in the Association Between Disease Complications and Markers of Oxidative Stress in Type 2 Diabetes Mellitus: A Cross-Sectional Study.Health science reports · 2026Article
- Article
- Managing diabetic ketoacidosis in special conditions: Difficulties and dilemmas.World journal of diabetes · 2025Review
- All-cause mortality risk following diabetic avoidable hospitalization among older patients with type 2 diabetes mellitus: a nationwide retrospective cohort study in South Korea.BMC public health · 2025Article
- DEKODE-A cloud-based performance feedback model improved DKA care across multiple hospitals in the UK.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Article
- Comparison of clinical characteristics and treatment outcomes between initially diagnosed type 1 and type 2 diabetes mellitus patients presenting with diabetic ketoacidosis.BMC endocrine disorders · 2024Article
- The prevalence, hospitalization outcomes and risk factors of euthyroid sick syndrome in patients with diabetic ketosis/ketoacidosis.BMC endocrine disorders · 2023Article
- Differential evolution of diabetic ketoacidosis in adults with pre-existent versus newly diagnosed type 1 and type 2 diabetes mellitus.BMC endocrine disorders · 2023Article
- A perspective on treating type 1 diabetes mellitus before insulin is needed.Nature reviews. Endocrinology · 2023Review
- The role of medication adherence in the association between depressive symptoms and quality of life in older adults with type 2 diabetes mellitus.BMC geriatrics · 2023Article
- A retrospective study on comparison of clinical characteristics and outcomes of diabetic ketoacidosis patients with and without acute pancreatitis.Scientific reports · 2023Observational
- Using Technology to Improve Diabetes Care in Hospital: The Challenge and the Opportunity.Journal of diabetes science and technology · 2023Article
- An Audit of Factors Impacting the Time to Resolution of the Metabolic Parameters in Diabetic Ketoacidosis Patients.Cureus · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe explored the clinical and biochemical differences in demographics, presentation and management of diabetic ketoacidosis (DKA) in adults with type 1 and type 2 diabetes. RESEARCH DESIGN AND
methodsThis observational study included all episodes of DKA from April 2014 to September 2020 in a UK tertiary care hospital. Data were collected on diabetes type, demographics, biochemical and clinical features at presentation, and DKA management.
resultsFrom 786 consecutive DKA, 583 (75.9%) type 1 diabetes and 185 (24.1%) type 2 diabetes episodes were included in the final analysis. Those with type 2 diabetes were older and had more ethnic minority representation than those with type 1 diabetes. Intercurrent illness (39.8%) and suboptimal compliance (26.8%) were the two most common precipitating causes of DKA in both cohorts. Severity of DKA as assessed by pH, glucose and lactate at presentation was similar in both groups. Total insulin requirements and total DKA duration were the same (type 1 diabetes 13.9 units (9.1-21.9); type 2 diabetes 13.9 units (7.7-21.1); p=0.4638). However, people with type 2 diabetes had significantly longer hospital stay (type 1 diabetes: 3.0 days (1.7-6.1); type 2 diabetes: 11.0 days (5.0-23.1); p<0.0001).
conclusionsIn this population, a quarter of DKA episodes occurred in people with type 2 diabetes. DKA in type 2 diabetes presents at an older age and with greater representation from ethnic minorities. However, severity of presentation and DKA duration are similar in both type 1 and type 2 diabetes, suggesting that the same clinical management protocol is equally effective. People with type 2 diabetes have longer hospital admission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.