Evidence map›Paper›PMID 34879703›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Maternal Vascular Lesions in the Placenta Predict Vascular Impairments a Decade After Delivery.

Janet M Catov, Matthew F Muldoon, Robin E Gandley, Judith Brands, Alisse Hauspurg, Carl A Hubel, Marie Tuft, Mandy Schmella, Gong Tang, W Tony Parks

Open access · greenAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Observational
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  9. Long-term microvascular and blood pressure dysregulation after Preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  10. Review
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  12. Article
  13. Article
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  20. Placental syndromes and maternal cardiovascular health.Clinical science (London, England : 1979) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Janet M CatovDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, School of Medicine, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh PA (J.M.C., R.E.G., J.B., A.H., C.A.H.).ORCID 0000-0002-9551-851X
Matthew F MuldoonCardiology Division, Department of Medicine, University of Pittsburgh School of Medicine, PA (M.F.M.).ORCID 0000-0002-2111-6331
Robin E GandleyDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, School of Medicine, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh PA (J.M.C., R.E.G., J.B., A.H., C.A.H.).
Judith BrandsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, School of Medicine, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh PA (J.M.C., R.E.G., J.B., A.H., C.A.H.).
Alisse HauspurgDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, School of Medicine, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh PA (J.M.C., R.E.G., J.B., A.H., C.A.H.).
Carl A HubelDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, School of Medicine, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh PA (J.M.C., R.E.G., J.B., A.H., C.A.H.).
Marie TuftGraduate School of Public Health (M.T., G.T.), University of Pittsburgh, PA.
Mandy SchmellaSchool of Nursing (M.S.), University of Pittsburgh, PA.ORCID 0000-0003-3543-8048
Gong TangGraduate School of Public Health (M.T., G.T.), University of Pittsburgh, PA.ORCID 0000-0002-6247-4338
W Tony ParksDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Canada (W.T.P.).
University of Pittsburgh · USMagee-Womens Research Institute · USTD Bank Group · CA

Funding

Building Research Careers in Women's HealthK12HD043441 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SADOVSKY, YOEL · 2002 to 2023
$10.1M
American Heart Association-American Stroke Association 16SFRN27810001American Heart Association-American Stroke Association 16SFRN28340000NICHD NIH HHS K12 HD043441
6 · The paper itself

Abstract

Women with adverse pregnancy outcomes later experience excess hypertension and cardiovascular disease, but how the events are linked is unknown. Examination of the placenta may provide clues to vascular impairments after delivery. Maternal vascular malperfusion lesions (MVMs) were abstracted from clinical reports, validated and characterized using clinical guidelines and severity score. A total of 492 women (170 with MVMs and 322 without MVMs) participated in a study visit 8 to 10 years after delivery to assess blood pressure, cardiometabolic factors, and sublingual microvascular features using sidestream dark field imaging. Covariates included age, race, adverse pregnancy outcomes (preeclampsia, small for gestational age, and preterm birth), and health behaviors. Women with versus without MVM had a distinct sublingual microvascular profile comprised of (1) lower microvascular density (-410 μm/mm

Indexed as

Blood GlucoseBody Mass IndexAdultBlood PressureFemaleHeart Disease Risk FactorsHumansInfant, NewbornLipidsMiddle AgedPlacentaPregnancyPregnancy OutcomePremature BirthRegistriesRetrospective StudiesBlood GlucoseLipidsblood pressurehyperlipidemiasmicrovascular rarefactionplacentapregnancy

Identifiers

PMID34879703
PMCPMC9026545
OpenAlexW4200094496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.