Evidence map›Paper›PMID 34879483›Full record

SynthesisThe American journal of emergency medicine2021

Outcomes of atrial fibrillation in patients with COVID-19 pneumonia: A systematic review and meta-analysis.

Ming-Yue Chen, Fang-Ping Xiao, Lin Kuai, Hai-Bo Zhou, Zhi-Qiang Jia, Meng Liu, Hao He, Mei Hong

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  4. SARS-CoV-2 ORF 3a-mediated currents are inhibited by antiarrhythmic drugs.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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  16. Impact of New Onset Atrial Fibrillation in Hospitalized Patients with COVID-19. Results of the "ACO-VID" Registry.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ming-Yue ChenDepartment of Geriatrics, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Fang-Ping XiaoDepartment of Cardiology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Lin KuaiDepartment of Geriatrics, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hai-Bo ZhouDepartment of Cardiology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhi-Qiang JiaDepartment of Cardiology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Meng LiuDepartment of Cardiology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hao HeDepartment of Cardiology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Mei HongDepartment of Geriatrics, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Cardiology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: meihong@njmu.edu.cn.
Second Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, emerging evidence has suggested that atrial fibrillation (AF) has an epidemiological correlation with coronavirus disease 2019 (COVID-19). However, the clinical outcomes of AF in COVID-19 remain inconsistent and inconclusive. The aim of this study was to provide a comprehensive description of the impact of AF on the prognosis of patients with COVID-19 pneumonia.

methodsThree electronic databases (PubMed, Embase, and Web of Science) were searched for eligible studies as of March 1, 2021. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the associations between AF (preexisting and new-onset) and in-hospital mortality, post-discharge mortality, and ventilator use.

resultsA total of 36 individual studies were incorporated into our meta-analysis. The combined results revealed that preexisting AF was associated with increased in-hospital mortality (pooled OR: 2.07; 95% CI: 1.60-2.67; p < 0.001), post-discharge mortality (pooled OR: 2.69; 95% CI: 1.24-5.83; p < 0.05), and ventilator utilization (pooled OR: 4.53; 95% CI: 1.33-15.38; p < 0.05) in patients with COVID-19. In addition, our data demonstrated that new-onset AF during severe acute respiratory syndrome coronavirus 2 infection was significantly correlated with increased mortality (pooled OR: 2.38; 95% CI: 2.04-2.77; p < 0.001).

conclusionsThe presence of AF is correlated with adverse outcomes in patients with COVID-19 pneumonia, which deserves increased attention and should be managed appropriately to prevent adverse outcomes.

Indexed as

Atrial FibrillationCOVID-19Hospital MortalityHumansRespiration, ArtificialSurvival RateArrhythmiaAtrial fibrillationCOVID-19Meta-analysisMortality

Identifiers

PMID34879483
PMCPMC8483996
OpenAlexW3202252364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.