ArticleNeurobiology of aging2022
Cognitive reserve proxies, Alzheimer pathologies, and cognition.
Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Theoretical and practical challenges for capturing reserve and resilience in aging and Alzheimer's disease: A narrative review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Moderating effect of the domains of the cognitive reserve index questionnaire (CRIq) on longitudinal change slopes in episodic memory across the cognitive aging continuum.Scientific reports · 2026Article
- Do cognitive reserve proxies capture a common neural signature? A systematic review and meta-analysis of task-based fMRI studies.Psychoradiology · 2026Review
- Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Modifiable risk factor profiles moderate the effect of β-amyloid pathology on cognition in aging.Neurobiology of aging · 2025Article
- Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.Neurobiology of disease · 2024Article
- Association between sleep quality and cognitive impairment in older adults hypertensive patients in China: a case-control study.Frontiers in public health · 2024Article
- Effect of Cognitive Reserve on Physiological Measures of Cognitive Workload in Older Adults with Cognitive Impairments.Journal of Alzheimer's disease : JAD · 2023Article
- Cognitive reserve and the risk of postoperative neurocognitive disorders in older age.Frontiers in aging neuroscience · 2023Article
- Lifelong Cognitive Reserve, Imaging Markers of Brain Aging, and Cognitive Function in Dementia-Free Rural Older Adults: A Population-Based Study.Journal of Alzheimer's disease : JAD · 2023Article
- Article
- The moderating effect of cognitive reserve on cognitive function in patients with Acute Ischemic Stroke.Frontiers in aging neuroscience · 2022Article
- Effect of cognitive reserve on amnestic mild cognitive impairment due to Alzheimer's disease defined by fluorodeoxyglucose-positron emission tomography.Frontiers in aging neuroscience · 2022Article
- The role of cognitive reserve in white matter hyperintensities: from cognitive aging to Alzheimer's spectrum.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Cognitive reserve as a predictor of cognitive decline, but not age of diagnosis in patients with possible young-onset Alzheimer's disease: An underexplored population.Journal of Alzheimer's disease reportsArticle
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Authors and funding
19 authors.
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Abstract
This study aimed to explore the moderating effects of the frequently used cognitive reserve (CR) proxies [i.e., education, premorbid intelligence quotient (pIQ), occupational complexity (OC), and lifetime cognitive activity (LCA)] on the relationships between various in vivo Alzheimer's disease (AD) pathologies and cognition. In total, 351 [268 cognitively unimpaired (CU), 83 cognitive impaired (CI)] older adults underwent multi-modal brain imaging to measure AD pathologies and cognitive assessments, and information on CR proxies was obtained. For overall participants, only education moderated the relationship between Aβ deposition and cognition. Education, pIQ, and LCA, but not OC, showed moderating effect on the relationship between AD-signature cerebral hypometabolism and cognition. In contrast, only OC had a moderating effect on the relationship between cortical atrophy of the AD-signature regions and cognition. Such moderation effects of the CR proxies were similarly observed in CI individuals, but most of them were not in CU individuals. The findings suggest that the proposed CR proxies have different moderating effects on the relationships between specific AD pathologies and cognition.
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