ArticleInternational journal of radiation oncology, biology, physics2022
Tooth Failure Post-Radiotherapy in Head and Neck Cancer: Primary Report of the Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad) Study.
Article in International journal of radiation oncology, biology, physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02057510 (Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Endodontic Management Before, During and After Head and Neck Radiotherapy: Biological, Diagnostic and Clinical Considerations in Head and Neck Cancer Patients.International endodontic journal · 2026Review
- Conventional vs. 3D-printed complete dentures in an irradiated edentulous patient: a case report with clinical comparison.Medicine and pharmacy reports · 2026Article
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Direct radiation damage to human tooth under IMRT for head and neck cancer: physicochemical evidence supporting a non-salivary mechanism for radiation-related caries.Radiation and environmental biophysics · 2026Article
- Article
- Chronic Oral Complications of Oral Cancer Therapy.Dental clinics of North America · 2025Review
- Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.Oral diseases · 2025Observational
- Self-perceived oral health, general self-efficacy, and their relations to oral health conditions in head and neck cancer patients in Sweden-a prospective observational study.Frontiers in oral health · 2025Article
- Prevalence and risk factors of chronic oral complications in head and neck cancer therapies: A retrospective study.Medicina oral, patologia oral y cirugia bucal · 2024Observational
- Personalizing dental screening and prevention protocols in dentulous patients with oropharyngeal cancer undergoing radiotherapy: A retrospective cohort study.Clinical and translational radiation oncology · 2024Article
- Factors associated with oral hygiene compliance in patients treated with radiation therapy for head and neck cancer.Journal of the American Dental Association (1939) · 2024Observational
- Tooth-level predictors of tooth loss and exposed bone after radiation therapy for head and neck cancer.Journal of the American Dental Association (1939) · 2023Observational
- Oral health-related quality of life after radiation therapy for head and neck cancer: the OraRad study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Observational
- Survey of experiences and barriers to dental care post-head and neck cancer in OraRad study participants.Oral surgery, oral medicine, oral pathology and oral radiology · 2023Article
- Over 300 Radiation Caries Papers: Reflections From the Rearview Mirror.Frontiers in oral health · 2022Review
- Dental Evaluation Prior to Cancer Therapy.Frontiers in oral health · 2022Review
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Authors and funding
9 authors at 9 institutions in 1 country.
Funding
Abstract
purposeTo elucidate long-term sequelae of radiation therapy (RT) in head and neck cancer (HNC) patients, a multicenter, prospective study, Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad), was established with tooth failure as its primary outcome. We report tooth failure and associated risk factors. METHODS AND MATERIALS: Demographics and cancer and dental disease characteristics were documented in 572 HNC patients at baseline and 6, 12, 18, and 24 months after RT. Eligible patients were aged 18 or older, diagnosed with HNC, and receiving RT to treat HNC. Tooth failure during follow-up was defined as losing a tooth or having a tooth deemed hopeless. Analyses of time to first tooth-failure event and number of teeth that failed used Kaplan-Meier estimators, Cox regression, and generalized linear models.
resultsAt 2 years, the estimated fraction of tooth failure was 17.8% (95% confidence interval, 14.3%-21.3%). The number of teeth that failed was higher for those with fewer teeth at baseline (P < .0001), greater reduction in salivary flow rate (P = .013), and noncompliance with daily oral hygiene (P = .03). Patients with dental caries at baseline had a higher risk of tooth failure with decreased salivary flow. Patients who were oral-hygiene noncompliant at baseline but compliant at all follow-up visits had the fewest teeth that failed; greatest tooth failure occurred in participants who were noncompliant at baseline and follow-up.
conclusionsDespite pre-RT dental management, substantial tooth failure occurs within 2 years after RT for HNC. Identified factors may help to predict or reduce risk of post-RT tooth failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.