Evidence map›Paper›PMID 34879222›Full record

ArticleImmunity2022

Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4

Eunha Kim, Donggi Paik, Ricardo N Ramirez, Delaney G Biggs, Youngjun Park, Ho-Keun Kwon, Gloria B Choi, Jun R Huh

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06514573 (Effects of a Postbiotic Supplementation on Gastrointestinal and Core Symptoms in Autism Spectrum Disorder), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06514573 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of a Postbiotic Supplementation on Gastrointestinal and Core Symptoms in Autism Spectrum Disorder: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorIstituto Superiore di SanitàRan2025 to 2026Enrolled128ConditionsAutism Spectrum Disorder (ASD)ArmsSodium Butyrate, Placebo (cornstarch)
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.

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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eunha KimDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Donggi PaikDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Ricardo N RamirezDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Delaney G BiggsDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Youngjun ParkDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Ho-Keun KwonDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Gloria B ChoiThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: gbchoi@mit.edu.
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jun_huh@hms.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USMcGovern Institute for Brain Research · US

Funding

Bacterial metabolites controlling Th17 cellsR01DK110559 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUH, JUN R. · 2016 to 2024
$5.1M
Pregnancy influences maternal immune cell function and fetal brain developmentR01MH119459 · NIMH · HARVARD MEDICAL SCHOOL · PI Jun R. Huh · 2019 to 2026
$3.9M
Elucidating neural substrates that mediate autism-like behaviorsR01MH115037 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHOI, GLORIA · 2017 to 2021
$2.6M
NIDDK NIH HHS R01 DK110559NIMH NIH HHS R01 MH115037NIMH NIH HHS R01 MH119459
6 · The paper itself

Abstract

Children with autism spectrum disorders often display dysregulated immune responses and related gastrointestinal symptoms. However, the underlying mechanisms leading to the development of both phenotypes have not been elucidated. Here, we show that mouse offspring exhibiting autism-like phenotypes due to prenatal exposure to maternal inflammation were more susceptible to developing intestinal inflammation following challenges later in life. In contrast to its prenatal role in neurodevelopmental phenotypes, interleukin-17A (IL-17A) generated immune-primed phenotypes in offspring through changes in the maternal gut microbiota that led to postnatal alterations in the chromatin landscape of naive CD4

Indexed as

AnimalsAutism Spectrum DisorderCD4-Positive T-LymphocytesChildChromatinDisease Models, AnimalFecal Microbiota TransplantationFemaleGastrointestinal MicrobiomeHumansImmunizationInflammationInterleukin-17IntestinesMiceNeurodevelopmental DisordersChromatinInterleukin-17autism spectrum disorderCitrobactercolitisgut microbiotainflammatory bowel diseasesinterleukin-17Amaternal immune activationneurodevelopmental disorderspregnancy

Identifiers

PMID34879222
PMCPMC8755621
OpenAlexW4200172127

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.