ArticleJournal of neurophysiology2022
The role of neuronal excitation and inhibition in the pre-Bötzinger complex on the cough reflex in the cat.
Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Physiological mechanisms and therapeutic targets in chronic cough.Physiological reports · 2026Review
- Modeling insights into potential mechanisms of opioid-induced respiratory depression within medullary and pontine networks.Journal of neurophysiology · 2026Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Effects of propofol on the electrophysiological properties of glutamatergic neurons in the ventrolateral medulla of mice.BMC anesthesiology · 2024Article
- Afferent and Efferent Connections of the Postinspiratory Complex (PiCo) Revealed by AAV and Monosynaptic Rabies Viral Tracing.The Journal of comparative neurology · 2024Article
- β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease.International journal of biological sciences · 2023Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Brainstem respiratory neuronal network significantly contributes to cough motor pattern generation. Neuronal populations in the pre-Bötzinger complex (PreBötC) represent a substantial component for respiratory rhythmogenesis. We studied the role of PreBötC neuronal excitation and inhibition on mechanically induced tracheobronchial cough in 15 spontaneously breathing, pentobarbital anesthetized adult cats (35 mg/kg, iv initially). Neuronal excitation by unilateral microinjection of glutamate analog d,l-homocysteic acid resulted in mild reduction of cough abdominal electromyogram (EMG) amplitudes and very limited temporal changes of cough compared with effects on breathing (very high respiratory rate, high amplitude inspiratory bursts with a short inspiratory phase, and tonic inspiratory motor component). Mean arterial blood pressure temporarily decreased. Blocking glutamate-related neuronal excitation by bilateral microinjections of nonspecific glutamate receptor antagonist kynurenic acid reduced cough inspiratory and expiratory EMG amplitude and shortened most cough temporal characteristics similarly to breathing temporal characteristics. Respiratory rate decreased and blood pressure temporarily increased. Limiting active neuronal inhibition by unilateral and bilateral microinjections of GABA
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