Observational studyAmerican journal of respiratory and critical care medicine2022
Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19.
Abstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections.Communications biology · 2025Pooled it
- Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial.Critical care (London, England) · 2023Trial
- Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients.The European respiratory journal · 2022Trial
- Inflammation, Endothelial Dysfunction, and Frailty Over 3 Years in Survivors of COVID-19 ARDS vs Pneumonia.CHEST critical care · 2026Article
- A Comprehensive Review on Cardioprotective Biological Properties of Crataegus orientalis in Post-COVID-19 Pandemic Cardiovascular Disorders.Molecular nutrition & food research · 2026Review
- Heparin-binding protein and Endothelin-1 in critical COVID-19.BMC anesthesiology · 2026Article
- Performance of the Ventilatory Ratio to Predict Intubation in Patients With COVID-19 Acute Respiratory Distress Syndrome.Critical care explorations · 2026Article
- Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID.Clinical proteomics · 2026Review
- Post-Acute Sequelae of COVID-19 Persist Over 3 Years in Acute Lung Injury/Acute Respiratory Distress Syndrome Survivors But Are Not Associated With Persistent Thromboinflammation or Endothelial Dysfunction.Critical care explorations · 2026Article
- Integrated Analysis of Parenchymal and Vascular HRCT Patterns with Circulating Biomarkers in Severe COVID-19 Pneumonia.Diagnostics (Basel, Switzerland) · 2026Article
- Renin-angiotensin system activation and oxidative stress in hospitalized COVID-19 patients: a single-centre prospective observational study.Intensive care medicine experimental · 2026Article
- Observational
- The post-COVID-19 pulmonary sequelae: manifestations, mechanisms and treatment strategies.Journal of thoracic disease · 2025Review
- Transpulmonary bubble transit in patients hospitalised with COVID-19 pneumonia.BMJ open respiratory research · 2025Article
- Inflammatory, fibrotic and endothelial biomarker profiles in COVID-19 patients during and following hospitalization.Scientific reports · 2025Article
- Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with lung infection and tissue-damage biomarkers.Virus research · 2025Article
- Integrated renin angiotensin system dysregulation and immune profiles predict COVID-19 disease severity in a South African cohort.Scientific reports · 2025Article
- Plasma proteomic profiles correlate with organ dysfunction in COVID-19 ARDS.Physiological reports · 2025Article
- Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies.Signal transduction and targeted therapy · 2025Review
- Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19.Metabolites · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors.
Daniel E LeismanDepartment of Anesthesiology, Critical Care, and Pain Medicine.ORCID 0000-0001-9670-9425
Arnav MehtaMassachusetts General Hospital Cancer Center.
B Taylor ThompsonDepartment of Medicine.
Nicole C CharlandDepartment of Emergency Medicine, and.
Anna L K GonyeCenter for Cancer Research.
Irena GushterovaCenter for Cancer Research.
Kyle R KaysDepartment of Emergency Medicine, and.
Hargun K KhannaDepartment of Emergency Medicine, and.
Thomas J LaSalleCenter for Cancer Research.
Kendall M Lavin-ParsonsDepartment of Emergency Medicine, and.
Brendan M LilleyDepartment of Emergency Medicine, and.
Carl L LodensteinDepartment of Emergency Medicine, and.
Kasidet ManakongtreecheepCenter for Cancer Research.
Justin D MargolinDepartment of Emergency Medicine, and.
Brenna N McKaigDepartment of Emergency Medicine, and.
Maricarmen Rojas-LopezCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Brian C RussoCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Nihaarika SharmaCenter for Cancer Research.
Jessica TantivitCenter for Cancer Research.
Molly F ThomasCenter for Cancer Research.
Blair Alden ParryDepartment of Emergency Medicine, and.
Alexandra-Chloé VillaniMassachusetts General Hospital Cancer Center.
Moshe Sade-FeldmanMassachusetts General Hospital Cancer Center.
Nir HacohenMassachusetts General Hospital Cancer Center.
Michael R FilbinDepartment of Emergency Medicine, and.
Marcia B GoldbergCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-4266-9733
Funding
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1MSingle-cell genomic profiling to identify immune signatures of bacterial sepsis in humansR01AI153142 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FILBIN, MICHAEL, GOLDBERG, MARCIA B · 2021 to 2025
$5.0MNCATS NIH HHS UL1 TR002541NIAID NIH HHS R01 AI153142NIAID NIH HHS U19 AI082630
Abstract
PubMed holds no abstract for this paper.
Indexed as
Alveolar Epithelial CellsPatient AcuityAdultAgedBiomarkersCOVID-19Critical Care OutcomesEndotheliumFemaleHumansMaleMiddle AgedPulmonary AlveoliRenin-Angiotensin SystemRespiration, ArtificialRespiratory Distress SyndromeBiomarkersalveolar epithelial cellsCOVID-19endotheliumrenin-angiotensin systemrespiratory distress syndrome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.