Evidence map›Paper›PMID 34878919›Full record

ArticleJournal of virology2022

The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia.

Liting Shao, Kang Ning, Jianke Wang, Fang Cheng, Shengqi Wang, Jianming Qiu

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Liting ShaoBeijing Institute of Radiation Medicine, Beijing, China.
Kang NingDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Centergrid.412016.0, Kansas City, Kansas, USA.
Jianke WangDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Centergrid.412016.0, Kansas City, Kansas, USA.
Fang ChengDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Centergrid.412016.0, Kansas City, Kansas, USA.
Shengqi WangBeijing Institute of Radiation Medicine, Beijing, China.
Jianming QiuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Centergrid.412016.0, Kansas City, Kansas, USA.ORCID 0000-0001-9850-1695
University of Kansas Medical Center · USBeijing Radiation Center · CN

Funding

Viral and Host Determinants of Parvovirus ReplicationR01AI150877 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI150877
6 · The paper itself

Abstract

Human bocavirus 1 (HBoV1), an autonomous human parvovirus, causes acute respiratory tract infections in young children. HBoV1 infects well-differentiated (polarized) human airway epithelium cultured at an air-liquid interface (HAE-ALI). HBoV1 expresses a large nonstructural protein, NS1, that is essential for viral DNA replication. HBoV1 infection of polarized human airway epithelial cells induces a DNA damage response (DDR) that is critical to viral DNA replication involving DNA repair with error-free Y-family DNA polymerases. HBoV1 NS1 or the isoform NS1-70

Indexed as

Virus ReplicationDNA DamageDNA ReplicationDNA, ViralGenome, ViralHEK293 CellsHuman bocavirusHumansKu AutoantigenProtein BindingProtein DomainsRespiratory MucosaViral Nonstructural ProteinsViral Replication CompartmentsDNA, ViralKu AutoantigenNS1 protein, parvovirusViral Nonstructural ProteinsXrcc6 protein, humanDNA damageDNA replicationhuman airway epitheliaparvovirus

Identifiers

PMID34878919
PMCPMC8865542
OpenAlexW4200111437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.