Evidence map›Paper›PMID 34878901›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Novel

Harish E Chatrathi, Jason C Collins, Lynne A Wolfe, Thomas C Markello, David R Adams, William A Gahl, Achim Werner, Prashant Sharma

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Kidney international reports · 2025
    Article
  5. Review
  6. Familial Hyperkalemic Hypertension.Comprehensive Physiology · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Urinary extracellular vesicles and tubular transport.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Harish E ChatrathiNIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD.ORCID 0000-0001-6330-4915
Jason C CollinsStem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research (J.C.C., A.W.), National Institutes of Health, Bethesda, MD.
Lynne A WolfeNIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD.ORCID 0000-0001-7628-5741
Thomas C MarkelloNIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD.
David R AdamsNIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD.
William A GahlNIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD.
Achim WernerStem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research (J.C.C., A.W.), National Institutes of Health, Bethesda, MD.ORCID 0000-0003-1051-8447
Prashant SharmaNIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD.ORCID 0000-0002-1165-980X
National Institutes of Health · US

Funding

Human Biochemical GeneticsZIAHG000215 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI GAHL, WILLIAM · 2009 to 2025
$72.6M
Ubiquitin-dependent cell-fate decisions during human development and diseaseZIADE000749 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WERNER, ACHIM · 2018 to 2025
$14.1M
Intramural NIH HHS Z99 HG999999
6 · The paper itself

Abstract

Familial hyperkalemic hypertension is caused by pathogenic variants in genes of the CUL3 (cullin-3)-KLHL3 (kelch-like-family-member-3)-WNK (with no-lysine [K] kinase) pathway, manifesting clinically as hyperkalemia, metabolic acidosis, and high systolic blood pressure. The ubiquitin E3 ligase CUL3-KLHL3 targets WNK kinases for degradation to limit activation of the thiazide-sensitive NCC (Na-Cl cotransporter). All known variants in

Indexed as

Child, PreschoolCullin ProteinsHumansMaleProteomicsPseudohypoaldosteronismSignal TransductionSKP Cullin F-Box Protein LigasesCUL3 protein, humanCullin ProteinsSKP Cullin F-Box Protein Ligasesblood pressureextracellular vesicleshyperkalemiapseudohypoaldosteronismubiquitination

Identifiers

PMID34878901
PMCPMC8667186
OpenAlexW3217118112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.