Evidence map›Paper›PMID 34878888›Full record

ArticleJournal of virology2022

The Mouse Cytomegalovirus G Protein-Coupled Receptor Homolog, M33, Coordinates Key Features of

Jiawei Ma, Kimberley Bruce, Nicholas Davis-Poynter, Philip G Stevenson, Helen E Farrell

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiawei MaSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Australia.
Kimberley BruceSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Australia.
Nicholas Davis-PoynterSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Australia.
Philip G StevensonSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Australia.ORCID 0000-0002-3520-5060
Helen E FarrellSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Australia.ORCID 0000-0002-7214-2767
The University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Common to all cytomegalovirus (CMV) genomes analyzed to date is the presence of G protein-coupled receptors (GPCR). Animal models of CMV provide insights into their role in viral fitness. The mouse cytomegalovirus (MCMV) GPCR, M33, facilitates dendritic cell (DC)-dependent viremia, the extravasation of blood-borne infected DCs to the salivary gland, and the frequency of reactivation events from latently infected tissue explants. Constitutive G protein-coupled M33 signaling is required for these phenotypes, although the contribution of distinct biochemical pathways activated by M33 is unknown. M33 engages G

Indexed as

AnimalsCyclic AMP Response Element-Binding ProteinDendritic CellsGTP-Binding Protein alpha Subunits, Gi-GoHerpesviridae InfectionsLymph NodesMiceMice, Inbred BALB CMuromegalovirusMutationPhospholipase C betaReceptors, G-Protein-CoupledSalivary GlandsSignal TransductionViral ProteinsViremiaCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinGTP-Binding Protein alpha Subunits, Gi-GoPhospholipase C betaPlcb1 protein, mouseReceptors, G-Protein-CoupledViral Proteinsdendritic cellsG protein-coupled receptorsmouse cytomegalovirusviral pathogenesis

Identifiers

PMID34878888
PMCPMC8865439
OpenAlexW4200109272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.