Evidence map›Paper›PMID 34878887›Full record

ArticleJournal of virology2022

Identification of MicroRNAs That Stabilize p53 in Human Papillomavirus-Positive Cancer Cells.

Gustavo Martínez-Noël, Patricia Szajner, Rebecca E Kramer, Kathleen A Boyland, Asma Sheikh, Jennifer A Smith, Peter M Howley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gustavo Martínez-Noël *Department of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Patricia Szajner *Department of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Rebecca E KramerDepartment of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Kathleen A BoylandDepartment of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Asma SheikhDepartment of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Jennifer A SmithDepartment of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Peter M HowleyDepartment of Immunology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Harvard University · US

Funding

Molecular Biology of Oncogenic PapillomavirusesR35CA197262 · NCI · HARVARD MEDICAL SCHOOL · PI HOWLEY, PETER M · 2016 to 2022
$7.1M
HHS | NIH | National Cancer Institute (NCI) R35CA197262NCI NIH HHS R35 CA197262
6 · The paper itself

Abstract

Etiologically, 5% of all cancers worldwide are caused by the high-risk human papillomaviruses (hrHPVs). These viruses encode two oncoproteins (E6 and E7) whose expression is required for cancer initiation and maintenance. Among their cellular targets are the p53 and the retinoblastoma tumor suppressor proteins. Inhibition of the hrHPV E6-mediated ubiquitylation of p53 through the E6AP ubiquitin ligase results in the stabilization of p53, leading to cellular apoptosis. We utilized a live cell high-throughput screen to determine whether exogenous microRNA (miRNA) transfection had the ability to stabilize p53 in hrHPV-positive cervical cancer cells expressing a p53-fluorescent protein as an

Indexed as

AlphapapillomavirusApoptosisCell Line, TumorCyclin-Dependent Kinase Inhibitor p21HeLa CellsHigh-Throughput Screening AssaysHumansMicroRNAsOncogene Proteins, ViralProtein StabilityTumor Suppressor Protein p53Ubiquitin-Protein LigasesCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21MicroRNAsOncogene Proteins, ViralTP53 protein, humanTumor Suppressor Protein p53UBE3A protein, humanUbiquitin-Protein LigasesapoptosiscancerE6E6APHPVmiRNAp53papillomavirusscreen

Identifiers

PMID34878887
PMCPMC8865425
OpenAlexW4213419564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.