Evidence map›Paper›PMID 34878841›Full record

ArticleScience advances2021

Injury-induced ASCL1 expression orchestrates a transitory cell state required for repair of the neonatal cerebellum.

N Sumru Bayin, Dogukan Mizrak, Daniel N Stephen, Zhimin Lao, Peter A Sims, Alexandra L Joyner

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Spatiotemporal histogenesis of the developing human cerebellum reveals dynamic layering of Bergmann glia.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Age-dependent regenerative mechanisms in the brain.Biochemical Society transactions · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

N Sumru BayinDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.ORCID 0000-0003-4371-855X
Dogukan MizrakDepartment of Systems Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-9885-9686
Daniel N StephenDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Zhimin LaoDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Peter A SimsDepartment of Systems Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-3921-4837
Alexandra L JoynerDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.ORCID 0000-0001-7090-9605

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Engrailed genes and cerebellum morphology, spatial gene expression and circuitryR37MH085726 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2014 to 2023
$6.7M
Signaling Pathways that Regulate Scaling and Regeneration of the CerebellumR01NS092096 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2015 to 2024
$4.8M
Single Cell Analysis of the Infiltrative Margins of Glioblastoma and Post Treatment RecurrenceR01NS103473 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JEFFREY N BRUCE, Peter Canoll · 2017 to 2026
$4.3M
Unraveling stem cell behaviors upon injury to the brainK99NS112605 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI BAYIN, NERMIN SUMRU · 2019 to 2020
$188k
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA013696NIMH NIH HHS R37 MH085726NINDS NIH HHS K99 NS112605NINDS NIH HHS R01 NS092096NINDS NIH HHS R01 NS103473
6 · The paper itself

Abstract

To understand repair processes, it is critical to identify the molecular foundations underlying progenitor diversity and plasticity. Upon injury to the neonatal cerebellum, a normally gliogenic

Identifiers

PMID34878841
PMCPMC8654303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.