Evidence map›Paper›PMID 34878720›Full record

ArticleChembiochem : a European journal of chemical biology2022

Rational Design of a Cu Chelator That Mitigates Cu-Induced ROS Production by Amyloid Beta.

Suchitra Mitra, Kallol Talukdar, Pallavi Prasad, Sandeep K Misra, Shabana Khan, Joshua S Sharp, Jonah W Jurss, Saumen Chakraborty

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Suchitra MitraDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
Kallol TalukdarDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
Pallavi PrasadDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
Sandeep K MisraDepartment of Biomolecular Sciences, University of Mississippi, University, MS 38677, USA.
Shabana KhanNational Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
Joshua S SharpDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
Jonah W JurssDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-2780-3415
Saumen ChakrabortyDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-9256-2769
University of Mississippi · US

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
NIGMS NIH HHS P20 GM103620NIGMS NIH HHS P20 GM130460NIGMS NIH HHS R21 GM103460
6 · The paper itself

Abstract

Alzheimer's disease severely perturbs transition metal homeostasis in the brain leading to the accumulation of excess metals in extracellular and intraneuronal locations. The amyloid beta protein binds these transition metals, ultimately causing severe oxidative stress in the brain. Metal chelation therapy is an approach to sequester metals from amyloid beta and relieve the oxidative stress. Here we have designed a mixed N/O donor Cu chelator inspired by the proposed ligand set of Cu in amyloid beta. We demonstrate that the chelator effectively removes Cu from amyloid beta and suppresses reactive oxygen species (ROS) production by redox silencing and radical scavenging both in vitro and in cellulo. The impact of ROS on the extent of oxidation of the different aggregated forms of the peptide is studied by mass spectrometry, which, along with other ROS assays, shows that the oligomers are pro-oxidants in nature. The aliphatic Leu34, which was previously unobserved, has been identified as a new oxidation site.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesChelating AgentsCopperHumansLigandsReactive Oxygen SpeciesAmyloid beta-PeptidesChelating AgentsCopperLigandsReactive Oxygen Species

Identifiers

PMID34878720
PMCPMC9040527
OpenAlexW4200535075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.