ArticleEvolution; international journal of organic evolution2022
Sex-related differences in aging rate are associated with sex chromosome system in amphibians.
Article in Evolution; international journal of organic evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Widespread sex-biased gene expression reflects female-biased longevity in a species with environmental sex determination.bioRxiv : the preprint server for biology · 2025Article
- Sexual selection drives sex difference in adult life expectancy across mammals and birds.Science advances · 2025Article
- Longevity, Age-Specific Survival, and Mean Generation Time ofEcology and evolution · 2025Article
- Variation in adult sex ratios in tetrapods is linked to sex chromosomes through mortality differences between males and females.PLoS biology · 2025Article
- DNA methylation-based age prediction and sex-specific epigenetic aging in a lizard with female-biased longevity.Science advances · 2025Article
- X*Y females exhibit steeper reproductive senescence in the African pygmy mouse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The evolution of aging and lifespan.Trends in genetics : TIG · 2023Review
- HerpSexDet: the herpetological database of sex determination and sex reversal.Scientific data · 2023Article
- How much does the unguarded X contribute to sex differences in life span?Evolution letters · 2022Article
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
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Authors and funding
50 authors at 20 institutions in 18 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex-related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determination systems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due to an apparent lack of demographic data from clades including both XY (with heterogametic males) and ZW (heterogametic females) systems. Taking advantage of a unique collection of capture-recapture datasets in amphibians, a vertebrate group where XY and ZW systems have repeatedly evolved over the past 200 million years, we examined whether sex heterogamy can predict sex differences in aging rates and lifespans. We showed that the strength and direction of sex differences in aging rates (and not lifespan) differ between XY and ZW systems. Sex-specific variation in aging rates was moderate within each system, but aging rates tended to be consistently higher in the heterogametic sex. This led to small but detectable effects of sex chromosome system on sex differences in aging rates in our models. Although preliminary, our results suggest that exposed recessive deleterious mutations on the X/Z chromosome (the "unguarded X/Z effect") or repeat-rich Y/W chromosome (the "toxic Y/W effect") could accelerate aging in the heterogametic sex in some vertebrate clades.
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