Evidence map›Paper›PMID 34878649›Full record

ArticleJournal of surgical oncology2022

Simultaneous resection for synchronous colorectal cancer liver metastases: A feasibility clinical trial.

Pablo E Serrano, Sameer Parpia, Paul Karanicolas, Steven Gallinger, Alice C Wei, Marko Simunovic, Mohit Bhandari, Mark Levine

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Pablo E SerranoDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-3715-6880
Sameer ParpiaOntario Clinical Oncology Group, McMaster University, Hamilton, Ontario, Canada.
Paul KaranicolasDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2906-7682
Steven GallingerDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.
Alice C WeiDepartment of Surgery, Memorial Sloan Kettering Cancer Centre, New York City, New York, USA.
Marko SimunovicDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-2245-3468
Mohit BhandariDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.
Mark LevineDepartment of Health Research Methods, Evidence, and Impact,  McMaster University, Hamilton, Ontario, Canada.
Ontario Clinical Oncology Group · CAImpact · CAMemorial Sloan Kettering Cancer Center · USSunnybrook Health Science Centre · CAUniversity Health Network · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
McMaster University McMaster International Initiatives Micro-FundMcMaster University McMaster Surgical AssociatesNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

BACKGROUND AND

objectivesWe tested the feasibility of a simultaneous resection clinical trial in patients with synchronous colorectal cancer liver metastases to obtain the necessary information to plan a randomized trial.

methodsMulticenter feasibility single-arm trial enrolling patients with synchronous colorectal cancer liver metastases eligible for simultaneous resection. Prespecified criteria for feasibility were: proportion of eligible patients enrolled ≥66%, and the proportion of enrolled patients who completed simultaneous resection ≥75%. The prespecified 90-day major postoperative complication rate was 30%.

resultsOf 61 eligible patients from February 2017 to August 2019, 41 were enrolled (67%; 95% confidence interval [CI], 55%-78%), 32 underwent simultaneous resection (78%; 95% CI, 63%-88%). Four patients were not enrolled due to the surgeon's preference, three were due to the complexity of resection (right hepatectomy and low anterior resection). Intraoperative complications during liver resection (n = 4) and progression of disease (n = 4) were the main reasons for not undergoing simultaneous resection. The 90-day incidence of major complications was 41% (95% CI, 16%-58%) and the 90-day postoperative mortality was 6% (95% CI, 1.7%-20%).

conclusionAccording to prespecified criteria, enrolling patients with synchronous colorectal cancer liver metastases to a trial of simultaneous resection is feasible; however, it is associated with higher than anticipated 90-day postoperative complications.

Indexed as

AgedColorectal NeoplasmsFeasibility StudiesFemaleFollow-Up StudiesHepatectomyHumansLaparoscopyLiver NeoplasmsMaleMiddle AgedNeoplasms, Multiple PrimaryPrognosisProspective Studiesclinical trialcolorectal cancercolorectal liver metastasesfeasibilitysimultaneous resectionsynchronous metastases

Identifiers

PMID34878649
PMCPMC9896571
OpenAlexW4200336650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.