ArticleInvestigative ophthalmology & visual science2021
Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma.
Article in Investigative ophthalmology & visual science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Explainable Multimodal OCT and OCTA Analysis Reveals Structural and Vascular Features of Mild Glaucoma Across Ethnicities.Investigative ophthalmology & visual science · 2026Observational
- Reproducibility of VF, OCT, and OCTA in Glaucoma: A Prospective Multi-Visit Study.Translational vision science & technology · 2026Article
- Comparison of Macular Ganglion Cell-Inner Plexiform Layer Thickness and Sectoral Ratio Asymmetry Among Different Glaucoma Types.Diagnostics (Basel, Switzerland) · 2026Article
- Lycium barbarum glycopeptide confers neuroprotection in chronic ocular hypertensive rats: a study investigating visual function, retinal structure, microcirculation, and pyroptosis.Frontiers in pharmacology · 2026Article
- Comparison of OCT Structural Parameters and OCTA-Measured Retinal Vessel Density and Peripapillary Choroidal Microvasculature in Glaucoma and Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica.Journal of ophthalmology · 2026Article
- FRNet V2: A Lightweight Full-Resolution Convolutional Neural Network for OCTA Vessel Segmentation.Biomimetics (Basel, Switzerland) · 2025Article
- Detecting glaucoma worsening using optical coherence tomography derived visual field estimates.Scientific reports · 2025Article
- Enhancing the structure-function relationship in glaucoma using anatomical compensation of retinal nerve fibre layer.The British journal of ophthalmology · 2024Article
- Comparative of OCT and OCTA parameters in patients with early chronic angle-closure glaucoma and early pituitary adenoma.Scientific reports · 2024Article
- Detection and agreement of event-based OCT and OCTA analysis for glaucoma progression.Eye (London, England) · 2024Article
- Abilities of circumpapillary retinal nerve fiber layer thickness and vascular density to discriminate stages in primary open-angle glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements.American journal of ophthalmology · 2024Article
- Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent.Journal of clinical medicine · 2023Article
- Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.American journal of ophthalmology · 2023Article
- Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2022Article
- Comparison of machine learning approaches for structure-function modeling in glaucoma.Annals of the New York Academy of Sciences · 2022Article
- Multipressure Dial Goggle Effects on Circumpapillary Structure and Microvasculature in Glaucoma Patients.Ophthalmology. GlaucomaArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate modeling of the focal visual field (VF) loss by combining structural measurements and vascular measurements in eyes with early primary open-angle glaucoma (POAG). Methods: In this cross-sectional study, subjects with early glaucoma (VF mean deviation, ≥-6 dB) underwent optical coherence tomography (OCT) imaging, optical coherence tomography angiography (OCTA) imaging, and Humphrey 24-2 VF tests. Capillary perfusion densities (CPDs) were calculated after the removal of large vessels in the OCTA images. Focal associations between VF losses at the individual VF test locations, circumpapillary retinal nerve fiber layer (RNFL) thickness measurements from OCT, and CPDs were determined using nerve fiber trajectory tracings. Linear mixed models were used to model focal VF losses at each VF test location. Results: Ninety-seven eyes with early POAG (VF mean deviation, -2.47 ± 1.64 dB) of 71 subjects were included. Focal VF modeling using a combined RNFL-CPD approach resulted in a median adjusted R2 value of 0.30 (interquartile range [IQR], 0.13-0.55), whereas the RNFL-only and CPD-only approaches resulted in median values of 0.22 (IQR, 0.10-0.51) and 0.26 (IQR, 0.10-0.52), respectively. Seventeen VF locations with the combined approach had an adjusted R2 value greater than 0.50. Likelihood testing at each VF test location showed that the combined approach performed significantly better at the superior nasal VF regions of the eyes compared with the univariate approaches. Conclusions: Modeling of focal VF losses showed improvements when structural thickness and vascular parameters were included in tandem. Evaluation of VF defects in early glaucoma may benefit from considering both RNFL and OCTA characteristics.
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