Evidence map›Paper›PMID 34878491›Full record

ArticleJAMA dermatology2022

Evaluation of a Case Series of Patients With Generalized Pustular Psoriasis in the United States.

Megan H Noe, Marilyn T Wan, Arash Mostaghimi, Joel M Gelfand, Pustular Psoriasis in the US Research Group, Ritesh Agnihothri, April W Armstrong, Tina Bhutani, Alina Bridges, Nicholas Brownstone and 39 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors.

Megan H NoeDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Marilyn T WanDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Arash MostaghimiDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Joel M GelfandDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Pustular Psoriasis in the US Research Group
Ritesh AgnihothriDepartment of Dermatology, University of Rochester, School of Medicine & Dentistry, Rochester, New York.
April W ArmstrongDepartment of Dermatology, Keck Hospital of USC, University of Southern California Keck School of Medicine, Los Angeles.
Tina BhutaniDepartment of Dermatology, UCSF Medical Center, University of California, San Francisco School of Medicine.
Alina BridgesDepartment of Dermatology, Mayo Clinic Graduate School of Education, Rochester, Minnesota.
Nicholas BrownstoneDepartment of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco.
Melissa ButtDepartment of Dermatology, Pennsylvania State Hershey Medical Center, Hershey.
Kristina P Callis DuffinDepartment of Dermatology, University of Utah, Salt Lake City.
Christian CarrUniversity of Texas Southwestern Medical Center, Dallas.
Andrew CreadoreDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Katherine L DeNiroDivision of Dermatology, Department of Medicine, University of Washington, Seattle.
Sheena DesaiDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Arturo R DominguezDepartments of Dermatology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Emily K DuffyDivision of Dermatology, Department of Medicine, University of Washington, Seattle.
Janet A FairleyDepartment of Dermatology, University of Iowa Carver College of Medicine, Iowa City.
Alisa FemiaRonald O. Perelman Department of Dermatology, NYU Langone Hospitals, New York University Grossman School of Medicine, New York.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor.
Jessica A KaffenbergerDivision of Dermatology, The Ohio State University Wexner Medical Center, Columbus.
Kimberly L KatzDepartment of Dermatology, Medical College of Wisconsin, Milwaukee.
Stephanie T LeDepartment of Dermatology, University of California, Davis, Sacramento.
Edgar MartinezUniversity of Texas Southwestern Medical Center, Dallas.
Emanual MaverakisDepartment of Dermatology, University of California, Davis School of Medicine, Sacramento.
Bridget MyersUniversity of California, San Francisco School of Medicine, San Francisco.
Haley B NaikAssociate Editor, JAMA Dermatology.
Caroline A NelsonDivision of Dermatology, Department of Medicine, University of Washington, Seattle.
Alex G Ortega-LoayzaDepartment of Dermatology, Oregon Health and Science University School of Medicine, Portland.
Molly E PlovanichDepartment of Dermatology, University of Rochester, School of Medicine & Dentistry, Rochester, New York.
Lauren K RangelNew York University Grossman School of Medicine, New York.
Vignesh RaviUniversity of Southern California Keck School of Medicine, Los Angeles.
Vidhatha D ReddyUniversity of California, San Francisco School of Medicine, San Francisco.
Jamal Z SalehDepartment of Dermatology, Medical College of Wisconsin, Milwaukee.
Joslyn S KirbyAssociate Editor, JAMA Dermatology.
Jeena K SandhuDepartment of Dermatology, University of Southern California Keck School of Medicine, Los Angeles.
Hadir ShakshoukDepartment of Dermatology, Mayo Clinic, Rochester, Minnesota.
Bridget E ShieldsDepartment of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison.
Zakariyah Sharif-SidiDepartment of Dermatology, Medical College of Wisconsin, Milwaukee.
Jacob SmithOregon Health and Science University School of Medicine, Portland.
Amanda SteahrDepartment of Dermatology, University of Iowa Carver College of Medicine, Iowa City.
Atrin ToussiUniversity of California, Davis School of Medicine, Sacramento.
Karolyn A WanatDepartment of Dermatology, Medical College of Wisconsin, Milwaukee.
Bo WangDepartment of Dermatology, University of Michigan, Ann Arbor.
Brian M WeiYale School of Medicine, New Haven, Connecticut.
Annika WeinhammerDepartment of Dermatology, University of Wisconsin-Madison.
Scott D WorswickDepartment of Dermatology, Keck Hospital of USC, University of Southern California Keck School of Medicine, Los Angeles.
Alexander YangYale School of Medicine, New Haven, Connecticut.

Funding

Microbial Shifts and Immune Dysregulation in Hidradenitis Suppurativa PathogenesisK23AR074531 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAIK, HALEY · 2019 to 2023
$887k
Respiratory infections and vaccination behaviors in patients with chronic inflammatory skin diseasesK23AR073932 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI NOE, MEGAN H · 2018 to 2022
$766k
NIAMS NIH HHS K23 AR073932NIAMS NIH HHS K23 AR074531
6 · The paper itself

Abstract

importanceGeneralized pustular psoriasis (GPP) is a chronic, orphan disease with limited epidemiological data.

objectiveTo describe the clinical characteristics, treatments, longitudinal disease course, and disease-specific health care utilization among patients with GPP across the United States. DESIGN, SETTING, AND

participantsA retrospective longitudinal case series involving 95 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for GPP and were treated at 20 US academic dermatology practices between January 1, 2007, and December 31, 2018. MAIN OUTCOMES AND MEASURES: The primary outcome is to describe the patient characteristics, associated medical comorbidities, treatment patterns complications, and GPP-specific health care utilization.

resultsSixty-seven of 95 patients (70.5%) were women (mean age, 50.3 years [SD, 16.1 years]). In the initial encounter, 35 patients (36.8%) were hospitalized and 64 (67.4%) were treated with systemic therapies. In total, more than 20 different systemic therapies were tried. During the follow-up period, 19 patients (35.8%) reported hospitalizations at a median rate of 0.5 hospitalizations per year (IQR, 0.4-1.6). Women had a decreased risk of an emergency department or hospital encounter (odds ratio, 0.19; 95% CI, 0.04-0.83). CONCLUSIONS AND RELEVANCE: Generalized pustular psoriasis is a rare, chronic disease without standard treatment and is associated with continued health care utilization over time.

Indexed as

PsoriasisSkin Diseases, VesiculobullousAcute DiseaseAdultChronic DiseaseFemaleHumansMiddle AgedRetrospective StudiesUnited States

Identifiers

PMID34878491
PMCPMC8655659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.