ArticleeLife2021
Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Interneuron and glial mechanisms underlying V1 orientation map dynamics.IBRO neuroscience reports · 2026Article
- Early Development of Direction Selectivity in the Higher Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Iso-orientation bias of layer 2/3 connections unifies spontaneous, visually and optogenetically driven V1 dynamics.Nature communications · 2026Article
- Modular inhibitory coding in binary networks.Frontiers in network physiology · 2026Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Premature vision drives aberrant development of response properties in primary visual cortex.eLife · 2025Article
- Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Premature vision drives aberrant development of response properties in primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Developmental maturation of millimeter-scale functional networks across brain areas.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The developmental emergence of reliable cortical representations.Nature neuroscience · 2025Article
- Synapse-type-specific competitive Hebbian learning forms functional recurrent networks.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Developmental maturation of millimeter-scale functional networks across brain areas.bioRxiv : the preprint server for biology · 2024Article
- Self-organization of modular activity in immature cortical networks.Nature communications · 2024Article
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- All-optical interrogation of millimeter-scale networks and application to developing ferret cortex.Journal of neuroscience methods · 2024Article
- A Semi-supervised Pipeline for Accurate Neuron Segmentation with Fewer Ground Truth Labels.eNeuro · 2024Article
- Development of visual response selectivity in cortical GABAergic interneurons.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Intracortical inhibition plays a critical role in shaping activity patterns in the mature cortex. However, little is known about the structure of inhibition in early development prior to the onset of sensory experience, a time when spontaneous activity exhibits long-range correlations predictive of mature functional networks. Here, using calcium imaging of GABAergic neurons in the ferret visual cortex, we show that spontaneous activity in inhibitory neurons is already highly organized into distributed modular networks before visual experience. Inhibitory neurons exhibit spatially modular activity with long-range correlations and precise local organization that is in quantitative agreement with excitatory networks. Furthermore, excitatory and inhibitory networks are strongly co-aligned at both millimeter and cellular scales. These results demonstrate a remarkable degree of organization in inhibitory networks early in the developing cortex, providing support for computational models of self-organizing networks and suggesting a mechanism for the emergence of distributed functional networks during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.