Evidence map›Paper›PMID 34878317›Full record

ArticleMicrobiology spectrum2021

Evaluation of the ImmuView RSV Test for Rapid Detection of Respiratory Syncytial Virus in Adult Patients with Influenza-Like Symptoms.

E Larsson, S Johansson, O Frøbert, A Nordenskjöld, S Athlin

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

E LarssonDepartment of Infectious Diseases, Örebro Universitygrid.15895.30 Hospital, Örebro, Sweden.
S JohanssonSchool of Medical Sciences, Faculty of Medicine and Health, Örebro Universitygrid.15895.30, Örebro, Sweden.
O FrøbertDepartment of Cardiology, Faculty of Medicine and Health, Örebro Universitygrid.15895.30, Örebro, Sweden.
A NordenskjöldDepartment of Cardiology, Faculty of Medicine and Health, Örebro Universitygrid.15895.30, Örebro, Sweden.
S AthlinDepartment of Infectious Diseases, Örebro Universitygrid.15895.30 Hospital, Örebro, Sweden.ORCID 0000-0002-8730-6955
Örebro University · SEÖrebro University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid antigen tests may enhance the diagnostic yield of respiratory syncytial virus (RSV) infections, but studies have shown low sensitivity in adults. We evaluated the novel ImmuView RSV test in adult patients with influenza-like symptoms who were prospectively enrolled at three emergency departments in two Swedish hospitals during two influenza seasons, 2017 to 2018 and 2018 to 2019. The ImmuView RSV test was performed on nasopharyngeal swabs and results were compared to those of the BinaxNOW RSV test. In the first season, tests were performed on frozen samples, while unfrozen samples were used in the second season. For comparison, tests were also performed on selected samples from children. Of 333 included adult patients, the sensitivity of ImmuView and BinaxNOW was 27% for both tests and specificities were 98% and 100%, respectively. The interassay agreement was good (κ = 0.61). There was no significant difference in test performance between frozen and unfrozen samples. In samples from children, the sensitivities of ImmuView and BinaxNOW were 67% and 70%, respectively. In conclusion, the ImmuView RSV test showed low sensitivity and high specificity for identifying RSV in adult patients with influenza-like symptoms, comparable with the BinaxNOW RSV test. Rapid RSV testing is of limited value for diagnosing RSV infection in adults.

Indexed as

AdultAgedAged, 80 and overAntigens, ViralDiagnosis, DifferentialDiagnostic Tests, RoutineFalse Positive ReactionsFemaleHumansInfluenza, HumanMaleMiddle AgedPoint-of-Care TestingProspective StudiesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAntigens, Viralantigen detectioncommunity-acquired infectionsinfluenzainfluenza-like symptomsrespiratory syncytial virus

Identifiers

PMID34878317
PMCPMC8653817
OpenAlexW4200122368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.