Evidence map›Paper›PMID 34878310›Full record

ArticleMicrobiology spectrum2021

A Cold Chain-Independent Specimen Collection and Transport Medium Improves Diagnostic Sensitivity and Minimizes Biosafety Challenges of COVID-19 Molecular Diagnosis.

Vikram Saini, Priya Kalra, Manish Sharma, Chhavi Rai, Vikas Saini, Kamini Gautam, Sankar Bhattacharya, Shailendra Mani, Kanchan Saini, Sunil Kumar

Abstract readEvaluation Study
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Observational
  3. Comprehensive Review on Viral RNA Extraction Strategies for Enhanced Molecular Diagnostics.Interdisciplinary perspectives on infectious diseases · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vikram SainiLaboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.ORCID 0000-0002-0258-2871
Priya KalraLaboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
Manish SharmaDefence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Ministry of Defense, Delhi, India.
Chhavi RaiDefence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Ministry of Defense, Delhi, India.
Vikas SainiUniversity College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
Kamini GautamLaboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
Sankar BhattacharyaTranslational Health Science and Technology Institutegrid.464764.3 (THSTI), Faridabad, Haryana, India.
Shailendra ManiTranslational Health Science and Technology Institutegrid.464764.3 (THSTI), Faridabad, Haryana, India.
Kanchan SainiLaboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
Sunil KumarLaboratory of Infection Biology and Translational Research, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.

Funding

All-India Institute of Medical Sciences (AIIMS) A-COVID-54Defence Research and Development Organisation (DRDO) LSRB-375/SH&DD/2020Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR39032/ADV/90/285/2020Department of Science and Technology, Ministry of Science and Technology, India (DST) CRG/2018/004510HarGobind Innovative Young Biotechnologist Award BT/11/IYBA/2018/01
6 · The paper itself

Abstract

Equitable and timely access to COVID-19-related care has emerged as a major challenge, especially in developing and low-income countries. In India, ∼65% of the population lives in villages where infrastructural constraints limit the access to molecular diagnostics of COVID-19 infection. Especially, the requirement of a cold chain transport for sustained sample integrity and associated biosafety challenges pose major bottlenecks to the equitable access. Here, we developed an innovative clinical specimen collection medium, named SupraSens microbial transport medium (SSTM). SSTM allowed a cold chain-independent transport at a wide temperature range (15°C to 40°C) and directly inactivated SARS-CoV-2 (<15 min). Evaluation of SSTM compared to commercial viral transport medium (VTM) in field studies (

Indexed as

Containment of BiohazardsCOVID-19COVID-19 TestingCulture MediaHumansMolecular Diagnostic TechniquesReal-Time Polymerase Chain ReactionSARS-CoV-2Specimen HandlingCulture Mediabiosafetycold chainCOVID-19 testingdiagnosticsqRT-PCRSARS-CoV-2virologyVTM

Identifiers

PMID34878310
PMCPMC8653843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.