Evidence map›Paper›PMID 34878156›Full record

ArticleInternational journal of molecular medicine2022

Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways.

Yaqing Zhang, Yonghua Li, Qilong Wang, Dongyu Zheng, Xue Feng, Wei Zhao, Linlin Cai, Qingqing Zhang, Haitao Xu, Hailong Fu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yaqing Zhang *Department of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Yonghua Li *Department of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Qilong Wang *Department of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Dongyu ZhengDepartment of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Xue FengDepartment of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China.
Wei ZhaoDepartment of Obstetrics and Gynecology, Inner Mongolia Autonomous Region Corps Hospital of Chinese People's Armed Police Force, Hohhot, Inner Mongolia Autonomous Region 010040, P.R. China.
Linlin CaiDepartment of Anesthesiology, Wuxi People's Hospital, Wuxi, Jiangsu 214023, P.R. China.
Qingqing ZhangDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, P.R. China.
Haitao XuDepartment of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Hailong FuDepartment of Anesthesiology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Shanghai Changzheng Hospital · CNInner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine · CNShanghai Jiao Tong University · CNShanghai Pulmonary Hospital · CNWuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are an emerging therapeutic tool for the treatment of tissue injuries. In the present study, the protective effect of isolated exosomes from adipose‑derived stem cells (ADSCs‑exo) against hepatic ischemia‑reperfusion (I/R) injury was explored. Hepatic I/R injury was achieved by inducing ischemia for 60 min followed by reperfusion for 2 and 6 h. Pre‑treatment with ADSCs‑exo revealed a significant reduction in necrosis and apoptosis in liver tissue induced by I/R injury. Hypoxic oxidative stress was managed by exosome‑mediated reduced reactive oxygen species and increased superoxide dismutase that in turn protected mitochondrial damage and apoptosis. Reduction in inflammatory mediators such as IL‑1β and TNF‑α was also observed and protection of hepatocytes from I/R injury was evidenced by a significant decrease in biochemical markers of liver damage (alanine transaminase, aspartate transaminase and lactate dehydrogenase). Exosomal prostaglandin E2 (PGE2)‑mediated ERK1/2 and GSK‑3β phosphorylation were revealed to increase Bcl‑2 and decrease Bax expression with mitochondrial permeability transition pore‑inhibition which may be considered a prime mechanism of exosome‑mediated hepatoprotection. In conclusion, our results indicated that ADSCs‑exo pre‑treatment is effective in protecting liver I/R injury.

Indexed as

MAP Kinase Signaling SystemAnimalsApoptosisbcl-2-Associated X ProteinBiomarkersCyclic AMPDinoprostoneExosomesGlycogen Synthase Kinase 3 betaLipid PeroxidationLiverMaleMesenchymal Stem CellsModels, BiologicalNecrosisOxidative Stressbcl-2-Associated X ProteinBiomarkersCyclic AMPDinoprostoneGlycogen Synthase Kinase 3 betaadipose‑derived stem cellsERK/GSK‑3βexosomeshepatic ischemia‑reperfusion injuryoxidative stress

Identifiers

PMID34878156
PMCPMC8711591
OpenAlexW4200441014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.