Evidence map›Paper›PMID 34878043›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2021

Putative extensive and pre-extensive drug resistant-tuberculosis associated with unusual genotypes on the Thailand-Myanmar border.

Janisara Rudeeaneksin, Wiphat Klayut, Sopa Srisungngam, Supranee Bunchoo, Sarawut Toonkomdang, Thanee Wongchai, Nattagarn Chuenchom, Benjawan Phetsuksiri

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PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. A large geno-spatial cluster of multi-drug resistant tuberculosis outbreak in a western district of Thailand.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Janisara RudeeaneksinMinistry of Public Health, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Wiphat KlayutMinistry of Public Health, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Sopa SrisungngamMinistry of Public Health, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Supranee BunchooMinistry of Public Health, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Sarawut ToonkomdangMae Sot Hospital, Tak, Thailand.
Thanee WongchaiMae Sot Hospital, Tak, Thailand.
Nattagarn ChuenchomMae Sot Hospital, Tak, Thailand.
Benjawan PhetsuksiriMinistry of Public Health, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.ORCID http://orcid.org/0000-0001-6507-2898
Ministry of Public Health · THMaesot General Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive drug-resistant tuberculosis (XDR-TB) is highly life threatening and its diagnosis is usually difficult and time-consuming. Here we present the first two cases of XDR and pre-XDR-TB diagnosed in 2018 on the Thailand-Myanmar border, more specifically in Tak province. Rapid detection of XDR-TB was performed by loop-mediated isothermal amplification (LAMP), Xpert MTB/RIF, and line probe assays. Mutation analyses targeting rpoB, katG, inhA, gyrA and rrs genes showed an association with drug-resistant phenotypes, except for rifampicin resistance. Spoligotyping revealed uncommon Beijing and T2 genotypes and the analysis of M. tuberculosis interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) showed the presence of more polymorphisms. This report highlights the importance of the early detection of drug-resistant tuberculosis by molecular tests followed by phenotyping assays. Based on the up-to-date definition of XDR- and pre-XDR-TB, the susceptibility testing for bedaquiline and linezolid is required and the two reported cases may correspond to putative XDR-TB.

Indexed as

Extensively Drug-Resistant TuberculosisMycobacterium tuberculosisPharmaceutical PreparationsTuberculosis, Multidrug-ResistantAntitubercular AgentsDrug Resistance, Multiple, BacterialGenotypeHumansMicrobial Sensitivity TestsMutationMyanmarThailandAntitubercular AgentsPharmaceutical Preparations

Identifiers

PMID34878043
PMCPMC8660029
OpenAlexW4205111303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.