Evidence map›Paper›PMID 34878006›Full record

ArticleJournal of applied oral science : revista FOB2021

Evaluation of squamous cell carcinoma antigen 1 expression in oral squamous cell carcinoma (tumor cells and peritumoral T-lymphocytes) and verrucous carcinoma and comparison with normal oral mucosa.

Samira Derakhshan, Arvin Poosti, Amirnader Emami Razavi, Mohammad Amin Moosavi, Nazanin Mahdavi, Fereshteh Baghaei Naieni, Kambiz Kamyab Hesari, Amirsina Rahpeima

Open access · diamondAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied oral science : revista FOB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Samira DerakhshanTehran University of Medical Sciences, School of Dentistry, Oral and Maxillofacial Pathology Department, Tehran, Iran.
Arvin PoostiTehran University of Medical Sciences, School of Dentistry, Tehran, Iran.
Amirnader Emami RazaviTehran University of Medical Sciences, Cancer Institute of Iran, Iran National Tumor Bank, Tehran, Iran.
Mohammad Amin MoosaviNational Institute of Genetic Engineering and Biotechnology (NIGEB), Institute of Medical Biotechnology, Molecular Medicine Department, Tehran, Iran.
Nazanin MahdaviTehran University of Medical Sciences, School of Dentistry, Oral and Maxillofacial Pathology Department, Tehran, Iran.
Fereshteh Baghaei NaieniTehran University of Medical Sciences, School of Dentistry, Oral and Maxillofacial Pathology Department, Tehran, Iran.
Kambiz Kamyab HesariRazi Hospital, Tehran University of Medical Sciences, Dermatopathology Department, Tehran, Iran.
Amirsina RahpeimaTehran University of Medical Sciences, School of Dentistry, Tehran, Iran.ORCID http://orcid.org/0000-0001-6200-0477
Tehran University of Medical Sciences · IRIran University of Medical Sciences · IRNational Institute of Genetic Engineering and Biotechnology · IRRazi Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSquamous cell carcinoma antigen (SCCA) is used as a prognostic marker for recurrence of squamous cell carcinoma in various sites, including head and neck. Studies suggest that its high serum levels are correlated to some clinical features, such as nodal metastasis. However, it is still unknown if high SCCA in patients with SCCA tissue expression in tumor cells are related to peripheral T-lymphocytes. Therefore, we did this study to evaluate SCCA expression in squamous cell carcinoma and verrucous carcinoma and to compare it with normal oral mucosa, also investigating the correlation between serum-based and tissue-based antigen levels. METHODOLOGY: In this study, the immunohistochemistry (IHC) technique was used to determine the SCCA1 expression pattern in 81 specimens divided into 3 groups, including oral squamous cell carcinoma, verrucous carcinoma, and normal oral mucosa. Serum-based and tissue-based antigen levels of 20 oral squamous cell carcinoma cases were compared by the western blot assay. SCCA expression was also evaluated and compared in both tumor cells and peripheral T-lymphocytes by the immunofluorescence assay.

resultsOur results showed that the SCCA levels in SCC specimens were significantly lower than in verrucous carcinoma and normal and hyperplastic oral mucosa specimens. We found no correlation between the IHC expression of SCCA and serum levels. SCCA was well expressed in both tumor cells and peripheral T-lymphocytes.

conclusionDecreasing SCCA in SCC specimens suggested that SCC tumor cells may affect more than the serum levels of SCCA in some patients. In addition, expression of SCCA in peripheral T-lymphocytes showed that both tumor cells and T-lymphocytes may cause serum SCCA.

Indexed as

Carcinoma, Squamous CellCarcinoma, VerrucousHead and Neck NeoplasmsMouth NeoplasmsAntigens, NeoplasmBiomarkers, TumorHumansMouth MucosaSerpinsSquamous Cell Carcinoma of Head and NeckT-LymphocytesAntigens, NeoplasmBiomarkers, TumorSerpinssquamous cell carcinoma-related antigen

Identifiers

PMID34878006
PMCPMC8653806
OpenAlexW3216092556

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.