ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Joint modeling approaches for predicting conversion from mild cognitive impairment to Alzheimer's disease: A systematic review (1999-2025).Belitung nursing journal · 2026Review
- Neuropsychiatric Symptoms in Cerebral Amyloid Angiopathy: A Significant but Overlooked Association.Brain sciences · 2025Article
- The role of Life's Crucial 9 in cardiovascular disease incidence and dynamic transitions to dementia.Communications medicine · 2025Article
- Anxious-depressive symptoms and sleep disturbances across the Alzheimer disease spectrum.Nature. Mental health · 2025Article
- Mood Symptoms are Associated With Cognitive Status, Brain Amyloid-Beta Deposition, and Plasma Biomarkers.Depression and anxiety · 2025Article
- Prevalence, associated factors and impact of mild cognitive impairment in hospitalized older adults with Parkinson's disease: a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- The role of elevated depressive symptoms in the incident mild cognitive impairment in China: a 9-year prospective cohort study of middle-aged and older Chinese adults (2011-2020).Frontiers in psychiatry · 2025Article
- Specific Association of Worry With Amyloid-β But Not Tau in Cognitively Unimpaired Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Elucidating the Link Between Anxiety/Depression and Alzheimer's Dementia in the Australian Imaging Biomarkers and Lifestyle (AIBL) Study.Journal of epidemiology and global health · 2024Article
- An analysis of factors influencing cognitive dysfunction among older adults in Northwest China based on logistic regression and decision tree modelling.BMC geriatrics · 2024Article
- Resilience in Mild Cognitive Impairment (MCI): Examining the Level and the Associations of Resilience with Subjective Wellbeing and Negative Affect in Early and Late-Stage MCI.Behavioral sciences (Basel, Switzerland) · 2023Article
- Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain.PNAS nexus · 2023Article
- Anxiety adds the risk of cognitive progression and is associated with axon/synapse degeneration among cognitively unimpaired older adults.EBioMedicine · 2023Article
- Impact of hearing loss on cognitive function in community-dwelling older adults: serial mediation of self-rated health and depressive anxiety symptoms.Frontiers in aging neuroscience · 2023Article
- Prevalence of Mild Cognitive Impairment in Southern Regions of Colombia.Journal of Alzheimer's disease reports · 2023Article
- Interactions Between Neuropsychiatric Symptoms and Alzheimer's Disease Neuroimaging Biomarkers in Predicting Longitudinal Cognitive Decline.Psychiatric research and clinical practice · 2023Article
- Neuropsychiatric Symptoms and Commonly Used Biomarkers of Alzheimer's Disease: A Literature Review from a Machine Learning Perspective.Journal of Alzheimer's disease : JAD · 2023Review
- A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Comorbidities confound Alzheimer's blood tests.Nature medicine · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
introductionWe investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI).
methodsWe followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity.
resultsCortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58-12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI. DISCUSSION: Anxiety modified the association between PiB+ and incident MCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.