ReviewPaediatric anaesthesia2022
Developmental respiratory physiology.
Review in Paediatric anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- High-flow nasal cannula versus continuous positive airway pressure for noninvasive respiratory support in children with bronchiolitis: a meta-analysis of randomized controlled trials.Frontiers in pediatrics · 2026Pooled it
- Effect of neuromuscular blocking agents on tracheal intubation quality in paediatric patients: a systematic review using network meta-analysis and meta-regression.British journal of anaesthesia · 2025Pooled it
- Ventilation-Weaning Protocols in Children Admitted to Pediatric Intensive Care Units: Systematic Review of Randomized Trials.Pediatric pulmonology · 2025Pooled it
- Measurement properties of outcome measurement instruments for pediatric dysfunctional breathing: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Silent Harm: How Ambient Air Pollution Threatens Prenatal and Neonatal Health. A Systematic Review.Investigacion y educacion en enfermeria · 2025Pooled it
- Effects of lung protective ventilation and conventional ventilation on postoperative atelectasis in neonates under general anesthesia.Frontiers in pediatrics · 2026Trial
- Respiratory oscillometry in infants: present challenges and future opportunities.Paediatric respiratory reviews · 2026Review
- Airway Intervention in Paediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- Unplanned Post-Operative Pediatric Intensive Care Unit Admissions After Elective Upper Airway Procedures: A Retrospective Case-Control Study.Paediatric anaesthesia · 2026Article
- Bench evidence, bedside uncertainty: hyperoxia, mechanical ventilation and lung injury.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- [Anesthesia in neonates and preterm infants : Current knowledge on ventilation, circulation and transfusion].Die Anaesthesiologie · 2026Review
- Development and Preliminary Validation of the Breath Motor Pattern Index (BMPI): An Observational Measure of Respiratory Pattern Quality in Children.Children (Basel, Switzerland) · 2026Article
- Toward reliable neuromuscular blockade reversal using sugammadex in infants: insights from a phase IV trial.Translational pediatrics · 2026Article
- Forgotten muscle: diaphragm and sudden infant death syndrome.World journal of pediatrics : WJP · 2026Article
- Severe Pertussis During Early Infancy from a High-Altitude Region: Two Clinical Cases and Literature Review.Journal of clinical medicine · 2026Article
- Understanding recurrent wheezing: A parent's guide.World journal of clinical pediatrics · 2026Article
- Review
- Brain activity as a candidate biomarker for personalised caffeine treatment in premature neonates.Frontiers in pediatrics · 2026Article
- A physiologic Comparison of Continuous Neurally Adjusted Ventilation (NeuroPAP) Versus Neurally-Adjusted Ventilatory Assist (NAVA) in Infants With Respiratory Failure.Pediatric pulmonology · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various developmental aspects of respiratory physiology put infants and young children at an increased risk of respiratory failure, which is associated with a higher rate of critical incidents during anesthesia. The immaturity of control of breathing in infants is reflected by prolonged central apneas and periodic breathing, and an increased risk of apneas after anesthesia. The physiology of the pediatric upper and lower airways is characterized by a higher flow resistance and airway collapsibility. The increased chest wall compliance and reduced gas exchange surface of the lungs reduce the pulmonary oxygen reserve vis-à-vis a higher metabolic oxygen demand, which causes more rapid oxygen desaturation when ventilation is compromised. This review describes the various developmental aspects of respiratory physiology and summarizes anesthetic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.