Evidence map›Paper›PMID 34877735›Full record

ArticleJournal of magnetic resonance imaging : JMRI2022

Deep Learning Reconstruction Enables Highly Accelerated Biparametric MR Imaging of the Prostate.

Patricia M Johnson, Angela Tong, Awani Donthireddy, Kira Melamud, Robert Petrocelli, Paul Smereka, Kun Qian, Mahesh B Keerthivasan, Hersh Chandarana, Florian Knoll

Registry-linked trialAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05820113 (Deep Learning Super Resolution Reconstruction for Fast and Motion Robust T2-weighted Prostate MRI), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05820113 nacompletednot on this map

Deep Learning Super Resolution Reconstruction for Fast and Motion Robust T2-weighted Prostate MRI

TypeinterventionalSponsorUniversity Hospital, BonnRan2022 to 2022Enrolled109ConditionsProstate Cancer, Multiparametric MRIArmsDeep learning based reconstruction of T2-TSE sequence
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. AI-accelerated prostate MRI: a systematic review.The British journal of radiology · 2024
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Image Quality and Diagnostic Performance of Accelerated T2-weighted Imaging of Prostate with Deep Learning Reconstruction: A Comparative Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Overcoming MRI accessibility barriers in cancer imaging with cutting-edge solutions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patricia M JohnsonCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0003-1547-9969
Angela TongCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.
Awani DonthireddyCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.
Kira MelamudCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.
Robert PetrocelliCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.
Paul SmerekaCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.
Kun QianDivision of Biostatistics, Department of Population Health, New York University School of Medicine, New York, New York, USA.
Mahesh B KeerthivasanMR R&D Collaborations, Siemens Medical Solutions USA Inc, New York, NY, USA.
Hersh ChandaranaCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.
Florian KnollCenter for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, USA.

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
Learning an Optimized Variational Network for Medical Image ReconstructionR01EB024532 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOHNSON, PATRICIA MARGARET, KNOLL, FLORIAN · 2018 to 2021
$1.8M
Low-Field High-Performance MRI for Screening Clinically Significant Prostate CancerR21CA256324 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANDARANA, HERSH · 2021 to 2022
$432k
NCI NIH HHS P41EB017183NCI NIH HHS R21 CA256324NCI NIH HHS R21 CA256324-01NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB024532
6 · The paper itself

Abstract

backgroundEarly diagnosis and treatment of prostate cancer (PCa) can be curative; however, prostate-specific antigen is a suboptimal screening test for clinically significant PCa. While prostate magnetic resonance imaging (MRI) has demonstrated value for the diagnosis of PCa, the acquisition time is too long for a first-line screening modality. PURPOSE: To accelerate prostate MRI exams, utilizing a variational network (VN) for image reconstruction. STUDY TYPE: Retrospective. SUBJECTS: One hundred and thirteen subjects (train/val/test: 70/13/30) undergoing prostate MRI. FIELD STRENGTH/SEQUENCE: 3.0 T; a T2 turbo spin echo (TSE) T2-weighted image (T2WI) sequence in axial and coronal planes, and axial echo-planar diffusion-weighted imaging (DWI). ASSESSMENT: Four abdominal radiologists evaluated the image quality of VN reconstructions of retrospectively under-sampled biparametric MRIs (bp-MRI), and standard bp-MRI reconstructions for 20 test subjects (studies). The studies included axial and coronal T2WI, DWI B50 seconds/mm STATISTICAL TESTS: One-sided Wilcoxon signed-rank test was used for comparison of image quality. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for lesion detection and grading. Generalized estimating equation with cluster effect was used to compare differences between standard and VN bp-MRI. A P-value of <0.05 was considered statistically significant.

resultsThree of four readers rated no significant difference for overall quality between the standard and VN axial T2WI (Reader 1: 4.00 ± 0.56 (Standard), 3.90 ± 0.64 (VN) P = 0.33; Reader 2: 4.35 ± 0.74 (Standard), 3.80 ± 0.89 (VN) P = 0.003; Reader 3: 4.60 ± 0.50 (Standard), 4.55 ± 0.60 (VN) P = 0.39; Reader 4: 3.65 ± 0.99 (Standard), 3.60 ± 1.00 (VN) P = 0.38). All four readers rated no significant difference for overall quality between standard and VN DWI B1000 seconds/mm DATA

conclusionDiagnostic accelerated biparametric prostate MRI exams can be performed using deep learning methods in <4 minutes, potentially enabling rapid screening prostate MRI. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 5.

Indexed as

Deep LearningProstatic NeoplasmsDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingMaleProstateRetrospective Studiesaccelerated imagingdeep learningimage reconstructionprostate MRI

Identifiers

PMID34877735
PMCPMC9170839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.