ReviewBrain, behavior, & immunity - health2021
The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes.
Review in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
- From placenta to the foetus: a systematic review of in vitro models of stress- and inflammation-induced depression in pregnancy.Molecular psychiatry · 2025Pooled it
- Pooled it
- Prenatal Origins of Stress Regulation: Maternal Psychological Distress and Inflammation During Pregnancy Prospectively Predict Infant Behavioral Reactivity and Regulation.Developmental psychobiology · 2026Article
- Inflammatory, clinical and sociodemographic factors associated with depressive disorder during pregnancy in Brazilian women.Scientific reports · 2026Article
- Research advances on estrogen deficiency leading to depression.Translational neuroscience · 2026Review
- Associations between prenatal inflammation and dimensions of depressive symptoms across the perinatal period.Psychoneuroendocrinology · 2025Article
- Unraveling the Metabolic and Microbiome Signatures in Fecal Samples of Pregnant Women with Prenatal Depression.Metabolites · 2025Article
- Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease.Expert review of clinical immunology · 2025Review
- Article
- Recurrent Pregnancy Loss: Immunological aetiologies and associations with mental health.Brain, behavior, & immunity - health · 2024Article
- Antibiotic or gastric acid inhibitor use during pregnancy and postpartum depression: Population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Protocol for a pilot study assessing a virtual mindfulness intervention for postpartum African American women.Brain behavior and immunity integrative · 2024Article
- Air Pollution and Perinatal Mental Health: A Comprehensive Overview.Journal of clinical medicine · 2023Review
- Psychosocial and behavioral factors affecting inflammation among pregnant African American women.Brain, behavior, & immunity - health · 2022Article
- Editorial commentary on the special issue emerging psychoneuroimmunology research: Future leaders in focus.Brain, behavior, & immunity - health · 2022Article
- Gut microbiota: Linking nutrition and perinatal depression.Frontiers in cellular and infection microbiology · 2022Review
- Inflammatory Mediators in the Pathway from Breastfeeding Difficulty to Postpartum Depression: A Systematic Review Following Moose Guidelines.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
- Antenatal depressive symptoms are strongly predicted by the severity of pre-menstrual syndrome: results of partial least squares analysis.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of inflammation in the pathogenesis of depression is becoming increasingly apparent, but its role in perinatal depression is less well-studied. Pregnancy and the postpartum are characterised by distinct and changing inflammatory profiles throughout, which makes the study of depression-related alterations in this period complex. This review presents literature discussing a role for the immune system in both antenatal and postnatal depression. Furthermore, literature investigating the role of the maternal immune system on breast milk composition and offspring immunological and behavioural outcomes is discussed, before concluding with suggestions for future work as this developing field grows.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.