Evidence map›Paper›PMID 34877398›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2021

Understanding Alzheimer's disease as a disorder of consciousness.

Jonathan D Huntley, Stephen M Fleming, Daniel C Mograbi, Daniel Bor, Lorina Naci, Adrian M Owen, Robert Howard

Abstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Mind Care: The Moral Significance of the Dementia Caregiving Dyad.The American journal of bioethics : AJOB · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Why brain organoids are not conscious yet.Patterns (New York, N.Y.) · 2024
    Review
  15. Article
  16. Article
  17. Lucidity in the Deeply Forgetful: A Scoping Review.Journal of Alzheimer's disease : JAD · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan D HuntleyDivision of Psychiatry University College London London UK.
Stephen M FlemingWellcome Centre for Human Neuroimaging University College London London UK.
Daniel C MograbiDepartment of Psychology Pontifical Catholic University of Rio de Janeiro Rio de Janeiro Brazil.
Daniel BorDepartment of Psychology University of Cambridge Cambridge UK.
Lorina NaciSchool of Psychology Global Brain Health Institute Trinity College Dublin Dublin Ireland.
Adrian M OwenBrain and Mind Institute Department of Physiology and Pharmacology and Department of Psychology University of Western Ontario London Ontario Canada.
Robert HowardDivision of Psychiatry University College London London UK.

Funding

Wellcome Trust 206648/Z/17/ZWellcome Trust 210920/Z/18/Z
6 · The paper itself

Abstract

People with Alzheimer's disease (AD) demonstrate a range of alterations in consciousness. Changes in awareness of cognitive deficit, self-awareness, and introspection are seen early in AD, and dysfunction of awareness and arousal progresses with increasing disease severity. However, heterogeneity of deficits between individuals and a lack of empirical studies in people with severe dementia highlight the importance of identifying and applying biomarkers of awareness in AD. Impairments of awareness in AD are associated with neuropathology in regions that overlap with proposed neural correlates of consciousness. Recent developments in consciousness science provide theoretical frameworks and experimental approaches to help further understand the conscious experience of people with AD. Recognition of AD as a disorder of consciousness is overdue, and important to both understand the lived experience of people with AD and to improve care.

Indexed as

Alzheimer's diseaseawarenessconsciousness

Identifiers

PMID34877398
PMCPMC8630359

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.