Evidence map›Paper›PMID 34877376›Full record

ArticleData in brief2021

A new test for autism spectrum disorder: Metabolic data from different cell types.

Sujata Srikanth, Lauren Cascio, Rini Pauly, Kelly Jones, Skylar Sorrow, Rossana Cubillan, Chin-Fu Chen, Cindy D Skinner, Kevin Champaigne, Roger E Stevenson and 2 more

Abstract read
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sujata SrikanthGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Lauren CascioGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Rini PaulyGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Kelly JonesGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Skylar SorrowGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Rossana CubillanGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Chin-Fu ChenGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Cindy D SkinnerGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Kevin ChampaigneCirca Bioscience, Greenwood, 113 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Roger E StevensonGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Charles E SchwartzGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Luigi BoccutoGreenwood Genetic Center, 101 Gregor Mendel Circle, Greenwood, SC 29646, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experiments employing the Phenotype Mammalian Microarray (PM-M) technology were performed on lymphoblastoid cell lines (LCLs) from individuals with autism spectrum disorder (ASD) and age-matched controls. We used the custom-made PM-M plate designed to assess differential utilization of the amino acid tryptophan. Multiple parameters such as the sample size, incubation time, and cell concentration have been tested, leading to optimized protocols and minimized background noise by variable selection while controlling for false discoveries. The assay generated data based on the production of nicotinamide adenine dinucleotide (NADH) in the presence of different compounds containing tryptophan and showed clear differences between ASD and control samples.

Indexed as

Autism spectrum disorder (ASD)Diagnostic testMetabolismScreening testTryptophan

Identifiers

PMID34877376
PMCPMC8633810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.