Evidence map›Paper›PMID 34877364›Full record

ArticleOpen forum infectious diseases2021

Coronavirus Disease 2019-Associated Invasive Fungal Infection.

John W Baddley, George R Thompson, Sharon C-A Chen, P Lewis White, Melissa D Johnson, M Hong Nguyen, Ilan S Schwartz, Andrej Spec, Luis Ostrosky-Zeichner, Brendan R Jackson and 2 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Managing Invasive Fungal Infections During Allogeneic Hematopoietic Transplantation: A 2025 Update.Mediterranean journal of hematology and infectious diseases · 2025
    Review
  11. Pulmonary aspergillosis in US Veterans with COVID-19: a nationwide, retrospective cohort study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Persistent fever after coronavirus disease 2019 in liver/kidney transplant recipient.Transplant infectious disease : an official journal of the Transplantation Society · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 4 countries.

John W BaddleyDepartment of Medicine, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-9111-625X
George R ThompsonDepartment of Internal Medicine, Division of Infectious Diseases and Department of Medical Microbiology and Immunology, University of California, Davis Medical Center, Sacramento, California, USA.
Sharon C-A ChenCentre for Infectious Diseases and Microbiology, Westmead Hospital and Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia.
P Lewis WhitePublic Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom.
Melissa D JohnsonDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
M Hong NguyenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ilan S SchwartzDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Andrej SpecDivision of Infectious Diseases, Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Luis Ostrosky-ZeichnerDivision of Infectious Diseases, McGovern Medical School, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-4784-7589
Brendan R JacksonCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Thomas F PattersonUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Peter G PappasDepartment of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Centers for Disease Control and Prevention · USDuke Medical Center · USThe University of Sydney · AUThe University of Texas Health Science Center at San Antonio · USUniversity Hospital of Wales · GBUniversity of Alabama at Birmingham · USUniversity of Alberta · CAUniversity of California Davis Medical Center · USUniversity of Maryland, Baltimore · USUniversity of Pittsburgh · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory therapy. Other risk factors include poorly controlled diabetes, structural lung disease and/or other comorbidities, and fungal colonization. Opportunistic IFI following severe respiratory viral illness has been increasingly recognized, most notably with severe influenza. There have been many reports of fungal infections associated with COVID-19, initially predominated by pulmonary aspergillosis, but with recent emergence of mucormycosis, candidiasis, and endemic mycoses. These infections can be challenging to diagnose and are associated with poor outcomes. The reported incidence of IFI has varied, often related to heterogeneity in patient populations, surveillance protocols, and definitions used for classification of fungal infections. Herein, we review IFI complicating COVID-19 and address knowledge gaps related to epidemiology, diagnosis, and management of COVID-19-associated fungal infections.

Indexed as

AspergilluscandidiasisCOVID-19endemic fungiPneumocystisSARS-CoV-2

Identifiers

PMID34877364
PMCPMC8643686
OpenAlexW3217196012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.