ArticleWorld journal of clinical cases2021
Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study.
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Diffuse Large B-Cell Lymphoma Masquerading as Cholangiocarcinoma in a Young Adult.ACG case reports journal · 2026Article
- Contrast-enhanced ultrasound findings of primary hepatic non-Hodgkin's lymphoma: a case report.Frontiers in oncology · 2024Article
- Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management.Frontiers in oncology · 2022Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe liver as a primary site of lymphoma is rarely seen, they are usually misdiagnosed as hepatocellular carcinoma,
aimTo investigate the clinical characteristics of patients with PHL.
methodsWe collected PHL cases on PubMed, and extracted demographic and clinicopathological data to perform a systematic analysis. Survival analysis regarding age, lactate dehydrogenase (LDH), liver function abnormality (LFA), and treatment modalities were conducted. The Kaplan-Meier method and Cox regression were used to identify risk factors.
resultsOf 116 PHL patients with DLBCL (62.1%) as the most common subtype. Biopsy methods before surgery produced a 97% positive rate. Progression-free survival (PFS) was significantly shortened in patients with elevated LDH [Hazard ratio (HR): 3.076, 95% confidence interval (CI): 1.207-7.840,
conclusionPHL patients with elevated LDH and LFA tend to have shorter PFS. Biopsy before treatment in undecided patients with no tumor markers exceeds upper limits has the most essential clinical significance, especially in immunoincompetent patients.
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