Evidence map›Paper›PMID 34877013›Full record

ArticleObesity science & practice2021

Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men.

Curtis Tilves, Joseph M Zmuda, Allison L Kuipers, Sangeeta Nair, John Jeffrey Carr, James G Terry, Shyamal Peddada, Victor Wheeler, Iva Miljkovic

Abstract read
In one paragraph

Article in Obesity science & practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Curtis TilvesDepartment of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0003-0281-5986
Joseph M ZmudaDepartment of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania USA.
Allison L KuipersDepartment of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania USA.
Sangeeta NairDepartment of Radiology Vanderbilt University Medical Center Nashville Tennessee USA.
John Jeffrey CarrDepartment of Radiology Vanderbilt University Medical Center Nashville Tennessee USA.
James G TerryDepartment of Radiology Vanderbilt University Medical Center Nashville Tennessee USA.
Shyamal PeddadaDepartment of Biostatistics University of Pittsburgh Pittsburgh Pennsylvania USA.
Victor WheelerTobago Health Studies Office Scarborough Tobago Trinidad and Tobago.
Iva MiljkovicDepartment of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania USA.

Funding

CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Cardiovascular Epidemiology Training ProgramT32HL083825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2008 to 2026
$6.1M
Epidemiology of Bone Loss in African MenR01AR049747 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M. · 2003 to 2014
$5.9M
Ectopic adiposity in black men with high type 2 diabetes riskR01DK097084 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2013 to 2016
$1.9M
Association of Type 2 Diabetes with Liver and Muscle Adiposity in Black MenR03DK092348 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2011 to 2012
$163k
NHLBI NIH HHS T32 HL007024NHLBI NIH HHS T32 HL083825NIAMS NIH HHS R01 AR049747NIDDK NIH HHS R01 DK097084NIDDK NIH HHS R03 DK092348
6 · The paper itself

Abstract

backgroundRegional body compositions are differentially associated with cardiometabolic risk factors. Simultaneous inclusion of both upper and lower body composition predictors in models is not often done, and studies which do include both measures (1) tend to exclude some tissue(s) of potential metabolic relevance, and (2) have used study populations with underrepresentation of individuals with African ancestries. Further, most body composition analyses do not employ compositional data analytic approaches, which may result in spurious associations.

objectiveThe objective of this analysis was to assess associations of abdominal and thigh adipose (AT) and muscle tissues with hypertension and type 2 diabetes using compositional data analytic methods. RESEARCH DESIGN AND

methodsThis cross-sectional analysis included 610 African Caribbean men (median age: 62 years; mean BMI: 27.8 kg/m

resultsA two-fold increase in ASAT:'Other' ratio was associated with higher continuous risk factors and with odds of being in a higher hypertension (OR: 1.77, 95%CI: 1.10-2.84) or diabetes (OR: 1.81, 95%CI: 1.06-3.10) category. A two-fold increased VAT ratio was only associated with higher log-insulin and log-HOMA-IR (

conclusionsThese findings support ASAT as a significant driver of cardiometabolic disease in African Ancestry populations, independent of other abdominal and thigh tissues.

Indexed as

body compositionhypertensiontype 2 diabetes

Identifiers

PMID34877013
PMCPMC8633926

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